The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamine, what is its history, what do we know about how and why it works, and how could it help hundreds of millions of people with depression and anxiety? Today’s guest is Boris Heifets. He is an assistant professor of anesthesiology at Stanford University and the author of a much talked about and utterly fascinating study on ketamine that came up with a brilliant way to test the effects of ketamine. The study's surprising results raise big questions about not only ketamine, but the curative power of belief. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Boris Heifets Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episoder(371)

Four Brilliant Frames for Finding the Next Big Thing, With Venture Capitalist Josh Wolfe. Plus, What's Eating Tech Stocks in 2022?

Four Brilliant Frames for Finding the Next Big Thing, With Venture Capitalist Josh Wolfe. Plus, What's Eating Tech Stocks in 2022?

All-star VC Josh Wolfe of Lux Capital joins the show to talk about picking winners and losers, tech's rough start to the year, and his four favorite mottos for detecting BS and seeing reality clearly....

22 Feb 202247min

The Great Debate: What's the Single Most Amazing Sports Statistic in U.S. History?

The Great Debate: What's the Single Most Amazing Sports Statistic in U.S. History?

Wilt Chamberlain’s 100-point game. Joe DiMaggio’s 56-game hit streak. Jerry Rice's gazillion receiving records. Which of these athletic achievements is the most impressive in American sports history? ...

18 Feb 202255min

What American Media Is Getting Wrong About Canada’s Big Protests

What American Media Is Getting Wrong About Canada’s Big Protests

What if I told you that the anti-vaccination trucker protests in Canada weren’t principally about vaccines or truckers (or even Canada)? The Atlantic’s David Frum joins to set us straight about what’s...

15 Feb 202226min

The Meaning of Life and the Power of Regret

The Meaning of Life and the Power of Regret

Derek goes deep with bestselling author Dan Pink on his new book, 'The Power of Regret.' This episode was recorded in front of a live audience at the Sixth & I historic synagogue in Washington, D.C. H...

11 Feb 202246min

Media Gossip Hour: Spotify's Joe Rogan Problem, Facebook's TikTok Crisis, and Crypto's Anonymity Conundrum

Media Gossip Hour: Spotify's Joe Rogan Problem, Facebook's TikTok Crisis, and Crypto's Anonymity Conundrum

Kevin Roose of The New York Times returns to our pod, which is owned by Spotify, to talk about Joe Rogan’s podcast, which is exclusively licensed by Spotify. (That's transparency, folks.) Then we talk...

8 Feb 202252min

This Guy Predicted the 2021 Economy. I Asked Him What's Next.

This Guy Predicted the 2021 Economy. I Asked Him What's Next.

Jason Furman is a Harvard professor who served as a top economist for the Obama administration. More than just about anybody Derek spoke to last year, he nailed the rise in inflation. What did he see ...

4 Feb 202248min

One Big Question For: Apple, Microsoft, Alphabet, Amazon, Tesla, and Meta

One Big Question For: Apple, Microsoft, Alphabet, Amazon, Tesla, and Meta

They’re the six largest tech companies in the world. What’s the most interesting thing about each of them? Shira Ovide, author of the On Tech newsletter from The New York Times, joins Derek to talk ab...

1 Feb 202242min

Should We Cancel Student Debt?

Should We Cancel Student Debt?

Americans owe $1.7 trillion in student loans, and some Democrats think the time has come to cancel this burden. Derek shares 10 big student-loan facts that shape the debate. Then Jordan Weissmann of S...

28 Jan 202237min

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