#197 Genetics for Weight Loss and Longevity - Joe Cohen

#197 Genetics for Weight Loss and Longevity - Joe Cohen

Welcome to the Body Mind Empowerment Podcast, I’m your host Siim Land and our guest today is Joe Cohen. Joe is the founder and CEO of Self-Hacked, which is one of the most popular biohacking websites online. He’s also founded SelfDecode, which is a genetics decoding company. Timestamps: How Joe Started to Research Genetics 01:35 The Power of Knowing Your Genetics 07:00 What Joe Found Out About His Genes 13:38 Your Genetics Doesn't Change 20:00 Who's Predisposed to COVID19 26:30 Inflammation and Anti-Inflammation 32:10 Mental Disorders and Depression Genetics 39:00 How to Assess Comorbidities 40:40 Siim's COVID19 DNA Report 46:16 Siim's Cardiovascular Disease Genes 49:10 Siim's Gut Health Genes 51:12 How Lifestyle Affects Genetics 01:00:10 And much more... Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon With SelfDecode you now have access to deep knowledge about your genetics and uniqueness. It's an invaluable tool for anyone wanting to custom tailor their diet, exercise, supplementation and self-care. You can get personalized health recommendations based on your DNA and the latest scientific research. They have numerous different DNA reports for different areas of focus like weight loss, longevity, gastrointestinal health, cognition, and even COVID19. I love SelfDecode and I advise everyone to get it. You can get a 10% discount with the code SIIM at get.selfdecode.com/siim Head over to get.selfdecode.com/siim and use the code SIIM for a 10% discount on your personalized DNA reports. Show Notes Use Code SIIM for 10% Off Self Decode Joe Cohen Instagram Self Hacked Blog Use Code SIIM for a 10% Discount on the KAATSU Bands Get Your Biomarkers Tested with Lets Get Checked At-Home Tests! Use Code SIIMLAND for a 20% Discount (sponsored)! My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim

Episoder(499)

#484 The Ultimate Health Tierlist - 100 Health Habits Ranked from Worst to Best

#484 The Ultimate Health Tierlist - 100 Health Habits Ranked from Worst to Best

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Timestamps:00:00 Intro00:15 Zone 2 cardio01:44 Napping03:03 Walking05:09 Polyphasic sleeping06:47 Mouth breathing07:52 Soleus pushups09:40 Stretching11:10 Mobility12:03 Yoga13:20 HIIT14:20 Sprinting14:48 Plyometrics16:12 Morning sunlight17:05 Evening sunset17:52 Blocking out blue light19:12 Red light therapy20:37 Infrared light21:43 Supplements23:30 Education25:20 Problem solving26:14 Weight lifting26:56 Bilingualism27:10 Sunbathing28:54 Tanning beds30:06 Coffee and teas31:28 Low carb diet33:26 Low fat high carb diet34:04 Vegan diet34:36 Vegetarian diet35:00 Carnivore diet37:07 Paleo diet37:45 Calisthenics39:15 Mediterranean diet40:20 Sugar diet40:58 Hydration41:42 Smoking42:00 Alcohol43:40 Vaping44:00 Mouth tobacco44:35 Hyperbaric oxygen therapy (HBOT)45:40 Sauna47:09 Total plasma exchange47:53 Meditation48:49 Religion50:10 Purpose51:30 Mindfulness52:14 Intermittent fasting53:15 Low calorie diet55:40 If it fits your macros diet57:30 Pet ownership58:57 Marriage01:00:57 Ice bath01:01:57 Having children01:03:29 Social health01:04:23 Having fun and play01:04:40 Mental health01:05:03 Extended fasting01:07:07 Forest bathing01:08:02 Fasting mimicking diet01:09:10 Juice fasting01:09:41 Dry fasting01:11:16 Protein restriction01:12:17 Hot baths01:13:40 Time-restricted eating01:14:10 Circadian mismatch01:14:50 Sleep consistency01:15:23 Chronic stress01:16:00 Junk food01:16:25 Water filtration01:16:50 Air filtration01:17:00 Outdoor pollution01:17:20 Sitting lifestyle01:17:43 Sleep 7-8 hours01:18:09 Regular bloodtests01:18:40 Continuous glucose monitoring01:19:19 Exercise snacks01:19:57 Standing workdesk01:20:53 Nasal breathing01:21:03 Breathing exercises01:21:38 Recreational drugs and weed01:22:26 Peptides01:23:30 HRT & TRT01:27:04 Sleep 4-6 hours01:27:28 Stem cell therapy01:28:17 Team sports01:28:40 Steroid cycle01:29:10 Grounding01:29:32 Mouth taping01:29:51 Artificial sweeteners01:31:30 Hypochondria01:33:50 OverviewMy 2025 supplement list guide: https://www.siimland.co/supplement-list-2025100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyiGet to top 1% health: https://youtu.be/8M9uHhFf26cStart rewinding your biological clock: https://www.siimland.co/course

22 Des 1h 35min

#483 Q&A Training fast twitch muscle fibers instead of lifting weights, How much protein for longevity, My all out supplement stack

#483 Q&A Training fast twitch muscle fibers instead of lifting weights, How much protein for longevity, My all out supplement stack

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 What level of sports performance is unhealthy04:15 How much protein is bad for aging and longevity11:45 Bon Charge sponsorship12:45 Do I want to reach the longevity escape velocity16:40 Absorbing supplements through the skin18:40 Optimal level of testosterone for longevity22:50 Should you cycle supplements on and off27:26 How I managed to follow a healthy lifestyle in my 20s31:07 How much red light therapy can you do per day33:10 Role of stress in longevity39:35 What to do against smog and air pollution43:50 Training fast twitch muscle fibers instead of lifting weights48:30 My all out supplement stack100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

13 Des 51min

#482 Why Scientists Believe Lithium May Be a Longevity Molecule

#482 Why Scientists Believe Lithium May Be a Longevity Molecule

Jon Berner, MD PhD is a board certified Psychiatrist from Seattle with 27 years of experience. He's also published several scientific papers.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:20 Why Dr Berner became interested in lithium04:50 Lithium’s benefits in Alzheimer’s and dementia10:50 Lithium’s effects on mTOR and autophagy12:50 Bon Charge sponsorship13:40 Clinical evidence for lithium in dementia18:20 What’s the optimal dose for lithium26:25 Lithium for bipolar and hyperactive brains29:25 Lithium as potential treatment in neurodegeneration31:55 Lithium’s effects on kidneys34:20 Personal experience with taking lithium40:40 Is it safe to take lithium prophalactically over the counter47:55 Rapamycin synergy with lithium51:45 AI and human developmentDr Berner's practice: https://www.woodinvillepsychiatric.com/100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

5 Des 1h 1min

#481 The Anti-Aging Pill Chinese Scientists Are Developing - Aiming for 120+ Lifespans - Yip Tszho

#481 The Anti-Aging Pill Chinese Scientists Are Developing - Aiming for 120+ Lifespans - Yip Tszho

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandYip (Zico) Tszho is the Chief Executive of Lonvi Biosciences, a longevity-drug start-up, in Shenzhen, China. They're developing pharmaceuticals for extending human lifespan. We discuss their first senolytic called PCC1. Timestamps:00:00 Intro00:15 Articles about a pill making people live to 15002:50 What is PCC1 and how is it made07:10 How much can targeting senescence extend lifespan12:25 Bon Charge sponsorship13:15 Dose of PCC1 for senolytic and senomorphic effects18:30 PCC1 extending lifespan in mice by 9.4%23:20 Absorption rate of PCC1 and other senolytics27:10 Senolytics for young vs old age31:10 Human study on PCC134:40 What’s the optimal dose for senolytics38:05 Biomarkers of cell senescence40:10 Senolytic benefits on skin and retina46:35 What’s going on in Chinese longevity science52:10 Future direction of PCC1PCC1 studies: https://lonvibio.com/pages/science

29 Nov 59min

#480 The Science of Saunas: How Heat Boosts Fitness & Longevity - Brady Holmer MSc

#480 The Science of Saunas: How Heat Boosts Fitness & Longevity - Brady Holmer MSc

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandBrady Holmer is a science writer and researcher with a Master's degree in Human Performance from the University of FloridaTimestamps:00:00 Intro00:40 Why heat acclimation has performance benefits08:10 How to train heat acclimation12:40 Bon Charge sponsorship13:30 Benefits of the sauna for fitness18:25 Saunas and injury recovery22:30 Cold exposure and exercise performance26:45 Cooling down during and before exercise31:40 How often to train heat acclimation and sauna37:05 Sauna and HRV38:10 How long to stay in the sauna41:15 Electrolytes and dehydration acclimation46:25 Differences between men and women in heat acclimation47:00 Does heat acclimation have longevity benefits49:05 Does cold exposure have longevity benefits54:30 Which research should be done more on heat acclimationFirst podcast with Brady about VO2 max: https://youtu.be/xLDaFhN6h8IBrady Holmer Twitter: https://x.com/B_HolmerBrady Holmer website: https://www.bradyholmer.com/Start rewinding your biological clock: https://www.siimland.co/course

21 Nov 59min

#479 Longevity Testing 101: What Really Matters (with Siim Land and Dr. Joy Kong)

#479 Longevity Testing 101: What Really Matters (with Siim Land and Dr. Joy Kong)

Join our upcoming retreat in January 2026: https://www.siimland.co/retreat Timestamps:Introduction (00:00)Discussion on longevity clinics and testing (01:52)Essential health tests and biomarkers (05:45)Improving VO2 Max and cardiovascular health (11:28)Blood tests and metabolic health (16:42)Hormone tests and longevity (21:35)Microbiome tests and toxicity (26:55)Microplastics and environmental toxicity (32:14)Food sensitivity testing (39:01)NAD testing and energy metabolism (41:50)Comprehensive health retreat (49:29)Dr. Joy Kong Youtube channel: https://www.siimland.co/retreat

14 Nov 1h 4min

#478 Mitochondria Scientist: The Only Proven Way to Extend Human Lifespan - Dr Mark Tarnopolsky

#478 Mitochondria Scientist: The Only Proven Way to Extend Human Lifespan - Dr Mark Tarnopolsky

Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en

8 Nov 59min

#477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner

#477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genesFirst podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUsTyler Panzner channel: https://www.youtube.com/@drtylerpanzner

31 Okt 1h

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