#359 Reversing Biological Aging and Extending Lifespan - Matt Kaeberlein PhD

Get your free personalized health review: https://www.siimland.co/reviewTimestamps:00:00 Intro01:10 Summary of our biomarker differences02:30 Fitness markers09:45 Body composition markers14:45 Inflammation and immune markers19:30 Metabolic health markers24:15 Cardiovascular markers36:30 Kidney markers43:45 Liver markers47:00 Hormone markers53:20 Experimental longevity tests56:45 PhenoAge biological age test01:01:40 RecapMy Evidence-Based Longevity Routine: https://youtu.be/4xkRcfeGDooStart rewinding your biological clock: https://www.siimland.co/course

23 Aug 1h 3min

Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025Timestamps:00:00 Intro00:16 Ca-AKG01:00 NAD Boosters02:54 Senolytics03:53 Glycine and trimethylglycine04:54 Glucosamine sulfate05:25 Taurine05:48 MSM and chondroitin sulfate06:18 Turmeric06:50 Ashwagandha07:52 Citrulline08:02 Thiamine08:40 Chromium09:14 Melatonin09:44 Theanine10:00 Rhodiola rosea10:24 Vitamin C11:01 Methylated B vitamins11:20 Ginger11:37 Sulforaphane11:52 Resveratrol and pterostilbene13:15 Rapamycin14:16 Metformin15:25 Spermidine and wheat germ16:50 Multivitamin17:40 Vitamin E tocotrienols18:10 Methylene blue18:49 Nicotine19:30 Lutein & zeaxanthin & lycopene20:41 Beta-carotene21:40 Molecular hydrogen22:10 Cocoa flavanols22:27 Spirulina22:58 Berberine23:25 Creatine24:14 Vitamin E tocopherol24:27 Aspirin25:35 Vitamin D326:45 Magnesium27:38 Collagen peptides28:10 Glutathione28:47 Vitamin K29:09 Carnosine29:36 Whey protein29:56 Amino acids31:09 Glutamine31:40 Psyllium husk32:08 Caffeine33:33 Aged garlic extract34:01 Ergothioneine34:46 Red yeast rice extract35:39 Tongkat ali36:06 DHEA36:40 Lithium37:52 Omega-338:18 SIRT638:41 NAC39:19 CoQ1040:01 PQQ40:32 Hyaluronic acid41:02 Boron41:20 Inositol41:30 Electrolytes42:35 Zinc43:08 Ginseng43:19 Shilajit43:44 Gingko biloba44:09 EGCG44:42 Tribulus terrestris45:15 Turkesterone45:45 MCT oil47:00 Iron47:40 GHK-Cu48:55 Iodine50:01 Calcium50:31 Beta-alanine51:09 HMB51:41 Saffron52:25 Probiotics and prebiotics53:45 Nattokinase54:32 Digestive enzymes55:11 AstaxanthinTop 15 Evidence-Based Supplements: https://youtu.be/jrozJ6oMEjo

16 Aug 56min

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Timestamps:00:00 Intro01:10 New research in cancer04:35 Circadian rhythms and chemotherapy07:55 Does living close to golf courts increase Parkinson’s and cancer risk11:35 Does glyphosate increase cancer risk13:40 Do you need to worry about cancer if you’re young17:20 Why cancer rates are rising in younger people21:00 Join my Skool community 22:10 Can stress and negative emotions cause cancer27:40 What does it feel to have cancer in the early stages30:35 How much exercise to reduce cancer risk35:15 Should you filter your tap water36:30 Difference between a benign tumor and cancerous tumor40:15 Can the body get rid of cancer on its own42:10 Should you avoid milk and cheese45:25 Processed meat and cured meats47:15 Why can some people live years with cancer49:00 Cancer risk from everyday household items51:35 Can you reverse damage from smoking and alcohol in the context of cancer54:15 Specific biomarkers for cancer risk56:15 Any supplements that have cancer preventive effectsDr Joe Zundell YouTube channel: https://www.youtube.com/@dr.joezundellDr Joe Zundell Instagram: https://www.instagram.com/dr.joezundell/Start rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

8 Aug 1h

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:35 Why exercise and physical activity matters05:05 What exercises does to your health12:15 Bon Charge Sponsorship13:05 Dangers of sedentary behavior14:00 Why exercise improves health20:25 Why you need to build a reserve23:35 Physionic’s current workout routine27:25 Greg’s current workout routine30:05 Siim’s current workout routine32:55 Cardio vs weights – which one is better47:25 How much exercise is too much55:10 Exercise and respiratory tract infections56:30 Arterial plaque in ultraendurance athletes01:06:25 How much moderate and vigorous exercise isbeneficial01:07:50 How long do athletes live01:14:45 Is too much resistance training harmful to you01:22:40 Protein intake and mortality01:27:15 Strength vs muscle vs power01:44:50 Physionic’s dumbest workout mistakes01:46:05 Greg’s dumbest workout mistakes01:49:00 Siim’s dumbest workout mistakes01:51:15 Youthspan Society Ad01:52:25 Why is VO2 max such a strong predictor of longevity02:06:40 Zone 2 cardio vs HIIT cardio02:16:00 Walking02:22:00 Balance and mobility02:31:40 Only one exercise we could do for the rest of ourlife02:35:45 Final thoughts Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Physionic Instagram: https://www.instagram.com/physionic_phd/ Physionic YouTube channel: https://www.youtube.com/@Physionic Join Youthspan Society community: https://www.skool.com/youthspan-society-9710/about

1 Aug 2h 37min

Get Bon Charge (Code SIIM): https://boncharge.com/siimlandTimestamps:00:00 Intro00:35 Is Detox a Scam05:20 How the body detoxifies itself16:18 Bon Charge sponsorship17:10 How to support daily detoxification pathways30:45 Mineral waters and mineral baths37:10 Do binders like clay and charcoal work41:10 Are there supplements that support detox45:55 Therapeutic detox therapies47:45 Fix your gut before detoxing55:45 Organic food, grass-fed, and water filters01:03:25 Protocol for mold illness01:18:18 Protocol for heavy metal toxicity01:23:25 Protocol for microplastics01:29:45 Anil’s new book Dr Anil Bajnath Instagram: https://www.instagram.com/dranilbajnath/Order my new book: https://www.amazon.com/dp/B0CW1B2XM1

25 Jul 1h 34min

Get Bon Charge (Code SIIM): https://boncharge.com/siimlandTimestamps:00:00 Intro00:18 Kristi’s new study on zone 2 cardio07:33 Does zone 2 provide unique mitochondrial benefits12:58 VO2 max15:18 Bon Charge sponsorship16:08 Why athletes do so much zone 2 training20:43 How much volume of exercise you need for mitochondrial adaptations25:43 Is zone 2 better than HIIT over a longer time period?32:38 How high heart rate for HIIT33:38 Training for athletes vs general population35:43 Too much high intensity training40:58 Why I do zone 2 training mostly44:18 The limited evidence about the optimal training protocol46:08 Did Kristi change her workout plan based on her research48:18 How long HIIT intervals are optimalKristi Storoschuk Instagram: https://www.instagram.com/krististoroschuk/

19 Jul 53min

Roundtable discussion with Dr. Greg Potter ( @gregpotterphd ) and Dr Nicolas Verhoeve ( @Physionic )Timestamps:00:00 Intro00:28 What supplements and/or pharmaceuticals we would give people05:58 Underrated longevity supplements08:35 Underrated medications13:40 The stupidest things we've done for health24:00 Omega-3 fatty acids (fish oil, algal oil) and longevity26:20 Vitamin D and longevity29:40 Do multivitamins affect longevity?34:45 Factors to consider when selecting longevity supplements50:50 The importance of when you take longevity supplements01:01:30 Supplement interactions with genetics, medications and lifestyle01:03:50 Longevity supplements and drugs that interfere with responses to exercise01:18:38 NAD+ -boosting supplements: effects on NAD+ and biomarkers of health and ageing01:34:00 Is resveratrol or pterostilbene good for longevity?01:39:40 Trigonelline and ergothioneine as alternative ways of raising NAD+01:41:30 Trace lithium as a longevity supplement01:44:20 (Calcium) AKG as a longevity supplement01:49:10 Glycine and glyNAC as longevity supplements02:04:20 Taurine as a longevity supplement02:09:35 Some longevity supplements might benefit vegans and vegetarians more02:13:35 Ergothioneine as a longevity supplement02:22:00 Might ergothioneine be a more effective way to increase NAD+?02:26:25 Astaxanthin as a longevity supplement02:31:05 Fatty15 and urolithin A02:35:50 The promise of nobiletin as a clock-enhancing supplementGreg Potter YouTube channel: https://www.youtube.com/@gregpotterphd Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Physionic Instagram: https://www.instagram.com/physionic_phd/ Physionic YouTube channel: https://www.youtube.com/@Physionic➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

12 Jul 2h 39min

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Timestamps:00:00 Intro00:58 How I started writing books04:28 Main keys of fat loss diets09:48 Supplements for fat loss10:33 Effects of diet sodas on fat loss13:48 Metformin effects on longevity17:38 How to optimize sleep23:33 Melatonin supplementation26:30 Calories and energy balance shortcomings30:15 Exercise32:25 Siim’s exercise plan38:45 Top tips for longevity based on research46:30 What’s next for me48:15 Advice for my younger selfCJ's YouTube channel: https://www.youtube.com/@shiftwithcj795 Top 15 supplements to take: https://www.youtube.com/watch?v=jrozJ6oMEjo&ab_channel=SiimLand

6 Jul 50min