Podcast #261: Icatibant

Podcast #261: Icatibant

Author: Aaron Lessen, M.D.

Educational Pearls

  • Icatibant was introduced to treat ACE-inhibitor induced angioendema.
  • This type of angioedema is refractory to epinephrine and antihistamines, and is likely mediated by elevated bradykinin.(which is inactivated by ATII and ACE).
  • Icatibant initially was shown to reduce facial swelling and airway obstruction in the setting of ACE-I angioedema, but later, better-powered studies showed that it had no benefit compared to standard treatment.

References: Sinert R et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017. PMID: 28552382

Episoder(1146)

Podcast #375: Retrograde Urethrogram

Podcast #375: Retrograde Urethrogram

Author: Jared Scott, MD Educational Pearls: Blood at urethral meatus in trauma can be a sign of bladder/urethral injury Blind placement of a Foley catheter can make an undiagnosed urethral injur...

6 Sep 20185min

Podcast #374:  Iliac Artery Endofibrosis

Podcast #374: Iliac Artery Endofibrosis

Author:  Sue Chilton, MD Educational Pearls:   An unusual cause of leg pain that can mimic sciatica/claudication Predominantly occurring in high endurance athletes, particularly cyclists and runner...

4 Sep 20183min

Podcast # 373: Legionnaires Disease

Podcast # 373: Legionnaires Disease

Author: Gretchen Hinson, MD Educational Pearls: Legionnaires disease refers to a severe pneumonia caused by Legionella pneumophilia and occurs typically at the extremes of age Associated gastroi...

1 Sep 20183min

Podcast # 372:  The Latest on Epinephrine in Cardiac Arrest

Podcast # 372: The Latest on Epinephrine in Cardiac Arrest

Author: Don Stader, MD Educational Pearls: 8014 patients with out-of-hospital cardiac arrest randomized to epinephrine vs placebo 30-day survival was not dramatically better between groups (3.2%...

30 Aug 20183min

Podcast # 371: EKG changes of Hyperkalemia

Podcast # 371: EKG changes of Hyperkalemia

Author: Jared Scott, MD Educational Pearls: EKG changes do not necessarily correlate to degree of hyperkalemia Traditional progression through peaked T-waves, flattened p-waves, QRS widening, an...

28 Aug 20183min

Podcast # 370:  Rapid Fire Neonatal Resuscitation

Podcast # 370: Rapid Fire Neonatal Resuscitation

Author:  Erik Verzemnieks, MD Educational Pearls:   In the panic of a precipitous ED delivery, remember: Warm. Dry. Stim.  It will solve most of your problems in most scenarios Start compressions i...

24 Aug 20181min

Podcast # 369:  Five powerful toxins - the definitive list?

Podcast # 369: Five powerful toxins - the definitive list?

Author: Michael Hunt, MD Educational Pearls: Here is a list of some very toxic natural substances:     #5: Tetrodotoxin: Found in pufferfish and other aquatic species #4: Ricin: made from castor beans...

22 Aug 20183min

Podcast # 368: Prehospital Plasma

Podcast # 368: Prehospital Plasma

Author: Aaron Lessen, MD Educational Pearls: Non-blinded randomized study assessing 30-day mortality benefit from plasma-first resuscitation in patients at risk hemorrhagic shock Study involved a...

20 Aug 20182min

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