Podcast 544: C is for Sepsis

Podcast 544: C is for Sepsis

Author: Aaron Lessen, MD

Educational Pearls:

  • Previously, trials had shown promising evidence that vitamin C may improve mortality rates in patients with sepsis or septic shock.
  • A 2017 retrospective before-after study gave a "cocktail" of hydrocortisone, vitamin C, and thiamine to patients with severe sepsis or in septic shock and reported a decrease in mortality from 40% to 8%.
  • A 2020 randomized controlled trial demonstrated that giving patients hydrocortisone, vitamin C, and thiamine showed no benefits in improving sepsis outcomes.
  • Currently use of Vitamin C in sepsis and septic shock remains controversial due to lack of sufficient data

References

1) Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229. Epub 2016 Dec 6.

2) Fujii T, Luethi N, Young PJ, et al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial. JAMA. 2020;323(5):423–431. doi:10.1001/jama.2019.22176

Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD



Episoder(1148)

Podcast 526:  Desmopressin for Intracranial Hemorrhage

Podcast 526: Desmopressin for Intracranial Hemorrhage

Contributor: Charleen Melton, PharmD Educational Pearls: Desmopressin (DDAVP) is an analogue of anti-diuretic hormone (ADH) that has been used for the treatment of intracranial hemorrhage. It works b...

30 Des 20193min

Podcast 525:  Enjoyable Epistaxis?

Podcast 525: Enjoyable Epistaxis?

Contributor: Jared Scott, MD Educational Pearls: The ED is full of painful procedures. One of the most commonly dreaded procedures is nasal packing for epistaxis, as it is quite uncomfortable for the...

24 Des 20193min

Podcast 524:  Bacterial Endocarditis

Podcast 524: Bacterial Endocarditis

Contributor: Sue Chilton, MD Educational Pearls: More intracardiac devices and injection drug abuse are thought to be increasing incidence of endocarditis Classic signs of endocarditis have included:...

20 Des 20193min

Podcast 523:  A Dizzying Diagnosis

Podcast 523: A Dizzying Diagnosis

Contributor: Don Stader, MD Educational Pearls: It can be difficult to distinguish between central and peripheral causes of vertigo. Cerebellar stroke should be considered with any dizzy patient.  Si...

17 Des 20192min

UnfilterED #3: Dr. Katie Bakes & Dr. Pete Bakes

UnfilterED #3: Dr. Katie Bakes & Dr. Pete Bakes

Husband and wife Pete and Katie Bakes, both emergency physicians in the Denver-Metro area, reflect on their upbringings, the many lessons learned over their twenty year careers, and how they've evolve...

14 Des 20191h 43min

Podcast 522: e-Cigarette and Vaping Related Lung Injury

Podcast 522: e-Cigarette and Vaping Related Lung Injury

Contributor: John Winkler, MD Educational Pearls: Vaping-related lung injury initially presents with flu-like symptoms and can progress to respiratory failure requiring aggressive resuscitation inclu...

10 Des 20192min

Podcast 521: Traumatic Hyphema

Podcast 521: Traumatic Hyphema

Author: Jared Scott, MD Educational Pearls: A hyphema is blood in the anterior chamber of the eye, typically caused by trauma While there is a spectrum of disease, blurred vision and eye pain are com...

5 Des 20192min

Podcast 520:  Approach to the arresting patient

Podcast 520: Approach to the arresting patient

Contributor: Peter Bakes, MD Educational Pearls: Peri-arrest patients present a particular challenge to ED providers, as the differential is broad and time is critical  The differential for near card...

3 Des 20197min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
jss
sinnsyn
forskningno
villmarksliv
liberal-halvtime
rss-rekommandert
fjellsportpodden
dekodet-2
rss-paradigmepodden
rss-overskuddsliv
tidlose-historier
tomprat-med-gunnar-tjomlid
utenrikshospitalet
katastrofe-i-hjernen
pod-britannia
rss-nysgjerrige-norge
rss-lundqvist-podden