Podcast 691: TXA in Head Bleeds

Podcast 691: TXA in Head Bleeds

Contributor: Ricky Dhaliwal, MD

Educational Pearls:

  • CRASH 3 Trial looked at over 12,000 patients with traumatic intracranial bleeds, randomizing patients to a therapy with TXA or standard of care without TXA
  • Dosing was 1 gram over 10 min for loading dose and then an infusion of 1 gram over 8 hours
  • Found Improvement in survival and neurologic outcomes when patient received TXA within 3 hours

References

CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial [published correction appears in Lancet. 2019 Nov 9;394(10210):1712]. Lancet. 2019;394(10210):1713-1723. doi:10.1016/S0140-6736(19)32233-0

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Episoder(1145)

Podcast 646: Thunderclap Headache, Think...RCVS?

Podcast 646: Thunderclap Headache, Think...RCVS?

Contributor: Aaron Lessen, MD Educational Pearls: When evaluating a thunderclap headache, don't forget RCVS! RCVS: reversible cerebral vasoconstriction syndrome Due to reversible spasms of cerebra...

8 Mar 20213min

Podcast 645: Necrotizing Enterocolitis and More

Podcast 645: Necrotizing Enterocolitis and More

Contributor:  Peter Bakes, MD Educational Pearls: Necrotizing Enterocolitis (NEC) Presents in the first few days of life (often in the NICU) to 3 weeks old Risk factors include prematurity, excess ...

2 Mar 20219min

Podcast 644: Covid Outcomes

Podcast 644: Covid Outcomes

Contributor: Aaron Lessen, MD Educational Pearls: Meta-analysis of 57,420 COVID+ patients evaluated mortality after intubation 45% mortality rate for all patients in the study 84.4% mortality in p...

1 Mar 20213min

Podcast 643: Convulsions with Gastroenteritis

Podcast 643: Convulsions with Gastroenteritis

Contributor: Jared Scott, MD Educational Pearls: Differential Diagnosis: non-accidental trauma, febrile seizure, meningitis, hyponatremia, epilepsy Convulsions with gastroenteritis is a known entity...

23 Feb 20215min

Podcast 642: Vasopressors

Podcast 642: Vasopressors

Contributor: Nick Tsipis, MD Educational Pearls: Epinephrine: alpha-1, alpha-2, beta-1, and beta 2 agonist - used in cardiac arrest with positive effects on ROSC in prehospital and peri-hopsital set...

22 Feb 20218min

Podcast 641: Leadless Intracardiac Pacemaker

Podcast 641: Leadless Intracardiac Pacemaker

Contributor: Jared Scott, MD Educational Pearls: Small capsule pacemaker (2.5 cm, 1 ml volume) resides in the heart without any associated wires or leads like a traditional pacemaker The new version ...

16 Feb 20216min

Podcast 640: Kawasaki's Disease

Podcast 640: Kawasaki's Disease

Contributor: Peter Bakes , MD Educational Pearls: Pediatric Fever + Rash Differential: scarlet fever, measles, rubella, chicken pox, fifth's disease, HHV-6, adenovirus, anaphylaxis, Kawasaki's diseas...

15 Feb 20215min

Pharmacy Phriday #9: Xofluza (Baloxavir marboxil) for Influenza

Pharmacy Phriday #9: Xofluza (Baloxavir marboxil) for Influenza

Contributor: Rachael Duncan, PharmD BCPS Educational Pearls:  According to the Department of Public Health and Environment who puts out a weekly report on the influenza virus in Colorado, there appea...

12 Feb 202112min

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