Emergency Medical Minute13 Sep 2021

Podcast 712: Cephalosporin with a Penicillin Allergy

Contributor: Aaron Lessen, MD

Educational Pearls:

Retrospective cohort study in the Kaiser system looked at over 4 million patients receiving antibiotics to determine the effect of penicillin allergy prompts in the EHR on antibiotic prescribing
Half of the sites removed prompts stating penicillin allergy and half kept the prompts
Patients with penicillin allergies who received cephalosporins went up from 20% to 27% in areas where the prompt was remove
No difference in mortality or no new allergies found between the two groups
Reduced the use of fluoroquinolones and clindamycin in the group without the prompt

References

Macy E, McCormick TA, Adams JL, et al. Association Between Removal of a Warning Against Cephalosporin Use in Patients With Penicillin Allergy and Antibiotic Prescribing. JAMA Netw Open. 2021;4(4):e218367. Published 2021 Apr 1. doi:10.1001/jamanetworkopen.2021.8367

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

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