Emergency Medical Minute28 Mar 2022

Podcast 767: Transaminitis and Rhabdomyolysis

Contributor: Sam Killian, MD

Educational Pearls:

Transaminitis refers to the elevation of transaminases, enzymes of the liver (AST and ALT)
Elevation of ALT is relatively specific to the liver, but AST is found in more organs than the liver including the muscle
If AST is significantly greater than ALT, consider a musculoskeletal origin such as rhabdomyolysis
Transaminitis is not always a liver specific issue

References

Lala V, Goyal A, Minter DA. Liver Function Tests. [Updated 2021 Aug 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482489/

Lim AK. Abnormal liver function tests associated with severe rhabdomyolysis. World J Gastroenterol. 2020;26(10):1020-1028. doi:10.3748/wjg.v26.i10.1020

Jo KM, Heo NY, Park SH, et al. Serum Aminotransferase Level in Rhabdomyolysis according to Concurrent Liver Disease. Korean J Gastroenterol. 2019;74(4):205-211. doi:10.4166/kjg.2019.74.4.205

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

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