Podcast 865: Nausea Treatments - Droperidol vs Ondansetron RCT

Podcast 865: Nausea Treatments - Droperidol vs Ondansetron RCT

Contributor: Aaron Lessen MD

Educational Pearls:

  • A recent randomized controlled trial compared ondansetron 8 mg IV with droperidol 2.5 mg IV for the treatment of nausea & vomiting in the emergency department.

  • Overall, droperidol and ondansetron had similar primary outcomes in acute nausea control

    • Symptom improvement in 93% of patients receiving droperidol vs. 87% receiving ondansetron (P = 0.362)

  • Secondary measures were, however, statistically significantly different between groups

    • Patients needed fewer rescue/additional antiemetics in the droperidol group (16%) compared with the ondansetron group (37%); p = 0.016

    • Similarly, more patients in the droperidol group reported they achieved the desired effect of the medication (85% vs. 63%; p = 0.006)

  • Patients receiving droperidol did experience increased drowsiness

    • 40% in the droperidol group vs. 11% in the ondansetron group

  • The trial did not assess the length of stay in the ED after administering medications, which is a potential avenue for future research.

References

1. Philpott L, Clemensen E, Lau GT. Droperidol versus ondansetron for nausea treatment within the emergency department. EMA - Emerg Med Australas. 2023;(December 2022):605-611. doi:10.1111/1742-6723.14174

Summarized & Edited by Jorge Chalit, OMSII

Episoder(1145)

Episode 913: Vasopressors after ROSC

Episode 913: Vasopressors after ROSC

Contributor: Travis Barlock MD Educational Pearls: Recent study assessed outcomes after ROSC with epinephrine vs. norepinephrine Observational multicenter study from 2011-2018 285 patients rece...

23 Jul 20241min

Podcast 912: Narcan (Naloxone)

Podcast 912: Narcan (Naloxone)

Contributor: Taylor Lynch, MD Educational Pearls: Opioid Epidemic- quick facts Drug overdoses, primarily driven by opioids, have become the leading cause of accidental death in the U.S. for individu...

15 Jul 20246min

Episode 911: Anticholinergic Toxicity

Episode 911: Anticholinergic Toxicity

Contributor: Taylor Lynch MD Educational Pearls: Anticholinergics are found in many medications, including over-the-counter remedies Medications include: Diphenhydramine Tricyclic antidepressa...

8 Jul 20247min

Episode 910: Cellulitis Recovery Timeline

Episode 910: Cellulitis Recovery Timeline

Contributor: Aaron Lessen, MD Educational Pearls: How fast does cellulitis recover? A recent prospective cohort study took a look at this question. The study included 300 adults with cellulitis ...

2 Jul 20241min

Episode 909: Prehospital Blood Pressure Management in Suspected Stroke

Episode 909: Prehospital Blood Pressure Management in Suspected Stroke

Contributor: Aaron Lessen MD Educational Pearls: A recent study assessed EMS treatment of high blood pressure in the field 2404 patients randomized to prehospital treatment (1205) vs. usual care ...

24 Jun 20242min

Episode 908: Sympathomimetic Drugs

Episode 908: Sympathomimetic Drugs

Contributor: Taylor Lynch MD Educational Pearls: Overview: Sympathomimetic drugs mimic the fight or flight response, affecting monoamines such as dopamine, norepinephrine, and epinephrine Limited th...

17 Jun 20247min

Episode 907: Wide-Complex Tachycardia

Episode 907: Wide-Complex Tachycardia

Contributor: Travis Barlock MD Educational Pearls: Wide-complex tachycardia is defined as a heart rate > 100 BPM with a QRS width > 120 milliseconds Wide-complex tachycardia of supraventricular or...

12 Jun 20243min

Episode 906: Case Study of Hypernatremia

Episode 906: Case Study of Hypernatremia

Contributor: Aaron Lessen MD Educational Pearls: The case: A gentleman came in from a nursing home with symptoms concerning for sepsis. He was hypotensive, hypoxic, febrile, and mentally altered. ...

3 Jun 20243min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
jss
vett-og-vitenskap-med-gaute-einevoll
smart-forklart
rss-nysgjerrige-norge
rss-rekommandert
forskningno
sinnsyn
fjellsportpodden
rss-paradigmepodden
villmarksliv
pod-britannia
nordnorsk-historie
aldring-og-helse-podden
diagnose
tidlose-historier
rss-overskuddsliv
tomprat-med-gunnar-tjomlid