Episode 905: Oseltamivir (Tamiflu) for Influenza

Episode 905: Oseltamivir (Tamiflu) for Influenza

Contributor: Aaron Lessem MD

Educational Pearls:

  • Oseltamivir (Tamiflu) is an antiviral medication used commonly to treat influenza

  • Trials show that the medication reduces the duration of illness by less than 1 day (~16 hours in one systematic review)

    • Benefit only occurs if taken within 48 hours of symptom onset

    • Must be taken for 5 days

  • A 2024 meta-analysis reviewed 15 randomized-controlled trials for the risk of hospitalization

    • No reduction in hospitalizations with oseltamivir in patients over the age of 12

    • No difference in high-risk patients over the age of 65 or those with comorbidities

      • The authors note that the confidence interval in these populations is wide, indicating a need for subsequent studies in high-risk populations

  • Oseltamivir is associated with adverse effects including nausea, vomiting, and neurologic symptoms

    • The risk of adverse effects may outweigh the benefits of a small reduction in the duration of illness

References

1. Hanula R, Bortolussi-Courval É, Mendel A, Ward BJ, Lee TC, McDonald EG. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699

2. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(April):1-18. doi:10.1136/bmj.g2545

Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit

Episoder(1145)

Podcast 591: Pediatric Documentation Pearls

Podcast 591: Pediatric Documentation Pearls

Emergency Medical Minute collaborated with CarePoint Health in early March for a night of education on Pediatric Emergencies at a local Denver brewery for our latest Brewcast. Pediatric patients requi...

31 Aug 202011min

Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

Pharmacy Phriday #2: Penicillin and Cephalosporin Allergies

The penicillin and cephalosporin drug classes include many first line drug options for infectious disease although high rates of self-reported allergies may cause physicians to seek alternative option...

28 Aug 202014min

Mental Health Monthly #4: Trauma, Loss and Grief in First Responders Heightened by COVID-19

Mental Health Monthly #4: Trauma, Loss and Grief in First Responders Heightened by COVID-19

Trauma and loss are common issues faced by emergency personnel and first responders. These challenges have since been heightened by the COVID-19 pandemic. On this installment of Mental Health Monthly,...

26 Aug 202020min

Podcast 590: Esophageal Food Impactions

Podcast 590: Esophageal Food Impactions

Contributor: Aaron Lessen, MD Educational Pearls: Carbonated beverages have shown efficacy in helping patients spontaneously pass esophageal food impactions Glucagon, while historically used for trea...

25 Aug 20202min

Podcast 589:  Management of Dental Trauma

Podcast 589: Management of Dental Trauma

Contributor: Peter Bakes, MD Educational Pearls: Dental fractures are described by the Ellis classifications, which are based on the involvement of layers of the teeth: Ellis I: involvement of the ...

24 Aug 20206min

Pharmacy Friday #1: Antibiotic Alternatives to Fluoroquinolones for Infectious Disease

Pharmacy Friday #1: Antibiotic Alternatives to Fluoroquinolones for Infectious Disease

Welcome to EMM's first Pharmacy Friday where we dive deeper on a certain pharmacological topic as it pertains to emergency medicine. Dr. Rachael Duncan, emergency medicine clinical Pharmacist, joins u...

21 Aug 202019min

Buprenorphine after Naloxone

Buprenorphine after Naloxone

EMM would like to extend a large thank you to the Pain Management and Addiction Medicine section of the American College of Emergency Physicians for allowing us to post their webinar panel discussion ...

19 Aug 20201h 18min

Podcast 588: Esmolol for Refractory Ventricular Fibrillation

Podcast 588: Esmolol for Refractory Ventricular Fibrillation

Contributor: Ricky Dhaliwal, MD, JD Educational Pearls: Ventricular Fibrillation (VF) is a potentially fatal cardiac arrhythmia; Refractory VF even more so Epinephrine stimulates alpha and beta recep...

18 Aug 20203min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
jss
vett-og-vitenskap-med-gaute-einevoll
smart-forklart
rss-nysgjerrige-norge
rss-rekommandert
forskningno
sinnsyn
fjellsportpodden
rss-paradigmepodden
villmarksliv
pod-britannia
nordnorsk-historie
aldring-og-helse-podden
diagnose
tidlose-historier
rss-overskuddsliv
tomprat-med-gunnar-tjomlid