Artesunate treatment in severely injured patients with traumatic haemorrhage
Multiple organ dysfunction syndrome (MODS) is common after major trauma, affecting up to two-thirds of patients with critical injuries. Post-trauma MODS is associated with a mortality of over 20% and ...
20 Sep 202318min
Life after sepsis in adult and paediatric patients
Sepsis is a life-threatening acute organ dysfunction secondary to infection and affects more than 19 million people annually. In 2017, it was estimated that almost 49 million people were infected by s...
13 Sep 202325min
Severe meningoencephalitis in the ICU: results from the EURECA study
Central nervous system (CNS) infections significantly burden ICU physicians' daily clinical work. Diagnosis can be challenging, and timely management is of the utmost importance. Meningoencephalitis i...
6 Sep 202318min
Diabetes mellitus in old critically ill COVID-19 patients
Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old, critically ill patients are particularly at risk. A recent multicentre inte...
30 Aug 202310min
Results from the TAME trial
International guidelines recommend targeting normocapnia in adults with coma resuscitated after out-of-hospital cardiac arrest. However, normocapnia may be insufficient to restore and maintain adequat...
27 Jun 202325min
Guidelines for the management of severe community-acquired pneumonia
Severe community‐acquired pneumonia (sCAP) is a clinical entity to describe ICU-admitted patients with community‐acquired pneumonia (CAP) as they might require organ support, and it is associated with...
24 Mai 202320min
Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis
Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Reduced renal clearance has the surprising and count...
17 Mai 202343min
How to manage coagulopathies in critically ill patients
Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Therefore, a review has ...
10 Mai 202320min
