298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Episoder(411)

AMA | September 2024

AMA | September 2024

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287 | Jean-Paul Faguet on Institutions and the Legacy of History

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286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

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19 Aug 20241h 20min

285 | Nate Silver on Prediction, Risk, and Rationality

285 | Nate Silver on Prediction, Risk, and Rationality

Being rational necessarily involves engagement with probability. Given two possible courses of action, it can be rational to prefer the one that could possibly result in a worse outcome, if there's al...

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AMA | August 2024

AMA | August 2024

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5 Aug 20243h 37min

284 | Doris Tsao on How the Brain Turns Vision Into the World

284 | Doris Tsao on How the Brain Turns Vision Into the World

The human brain does a pretty amazing job of taking in a huge amount of data from multiple sensory modalities -- vision, hearing, smell, etc. -- and constructing a coherent picture of the world, const...

29 Jul 20241h 2min

283 | Daron Acemoglu on Technology, Inequality, and Power

283 | Daron Acemoglu on Technology, Inequality, and Power

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22 Jul 20241h 17min

282 | Joel David Hamkins on Puzzles of Reality and Infinity

282 | Joel David Hamkins on Puzzles of Reality and Infinity

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