BONUS AMA: How to Navigate Fasting, Electrolytes, Hormonal Fluctuations, the Role of Carbs, and Fasting Troubleshooting

I am honored to reconnect with Dave Feldman today. Our last encounter was in December 2020, for Episode 128, where we delved deeply into the topic of cholesterol. Dave is an engineer by profession. He is profoundly clever and commands great respect within the low-carb and keto community due to his willingness to challenge prevailing narratives, encouraging us to explore alternative perspectives on lipid metabolism and reconsider our understanding of LDL, particularly in the context of lean mass hyper-responders like myself. In our discussion today, we dive into how LDL became so vilified, with Dave shedding light on several crucial research findings. We explain what low-mass hyper-responders are, examine biases and cognitive dissonance, touch on Dave’s new LMHR study, and discuss the Miami Heart study, a longitudinal study of the roles of LDL and plaque burden. We also explore the impact of ApoB and reflect on the essence of science as a pursuit of truth, and Dave shares what lies ahead for himself and his research. I trust you will find this conversation engaging and thought-provoking. IN THIS EPISODE YOU WILL LEARN: Why LDL is considered a villain  How AMRs and APB lipoproteins have influenced how we look at risk stratification What is a lean mass hyper-responder? How a low-carb, high-fat diet can improve the metabolic health of lean mass hyper-responders How Dave, an engineer turned scientist, challenges conventional wisdom in the health and wellness space Dave discusses a study on plaque progression in healthy individuals, focusing on correlating LDL levels  How we are at the forefront of finding the significance of lean mass hyper-responders and LDL Dave shares the next thing he and his team will look at to substantiate his findings on lean mass hyper-responders Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dave Feldman On his website Instagram X     Facebook Previous Episode Mentioned Ep. 128 – Cholesterol Obsession: Why It’s the Intellectual Property of the Animal Kingdom with Dave Feldman

27 Mar 202446min

I am delighted to have Dr. Colleen Cutcliffe, the CEO and Co-founder of Pendulum, joining me today.  Dr. Cutcliffe is a proud alumnus of Johns Hopkins, with over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotech. Before starting Pendulum, she was the Senior Manager of Biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals.  In our discussion today, we dive into the emerging science of the gut microbiome, examining the effects of aging, antibiotics, nutrition, stress, travel, and menopause on gut health and discussing how vaginal and C-section deliveries differ in impact. We explore differentiators for various categories of bacteria and the roles of butyrate and fiber, looking at fecal transplants and the difference between probiotics, prebiotics, and post-biotics, and explaining why Akkermansia is an essential bacteria for regulating insulin satiety, fortifying the mucin layer, and facilitating targeted delivery of butyrate. Dr. Cutcliffe also shares her top tips for mitigating the effects of travel on the gut microbiome and offers a special discount for listeners.  I am confident that you will find today’s discussion with Dr. Colleen Cutcliffe engaging and enlightening. Stay tuned to learn how to adjust your lifestyle for a healthier gut microbiome. IN THIS EPISODE YOU WILL LEARN: The benefits of a vaginal delivery Various factors that disrupt the gut microbiome Why it is essential to get enough fiber in your diet What are the signs and symptoms of an unhealthy gut microbiome? The benefits of fecal transplants How the vagus nerve fosters communication between the gut and brain Why artificial sweeteners might not be as harmful to the gut microbiome as previously thought How prebiotics, probiotics, and postbiotics are interconnected and necessary for overall health The role of Akkermansia in the gut microbiome How to maintain a healthy gut microbiome while traveling   Bio: Dr. Colleen Cutcliffe: Colleen Cutcliffe, PhD, is the CEO and Co-Founder of Pendulum. She has over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Before starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Colleen Cutcliffe On the Pendulum Life website Use code THURLOW for 20% off your first order of Pendulum products.

23 Mar 202455min

Today, I have the honor of connecting with Juraj Kocar, the CEO of Somavedic Technologies. Somavedic is a groundbreaking frequency therapy device providing practical and easily accessible solutions for EMF exposure, improved sleep, and energy revitalization.  Juraj is a perpetually optimistic and forward-thinking entrepreneur motivated by a profound passion for developing and expanding products that significantly impact the lives of others, and he is currently propelling his dream project to new levels of success. In our discussion today, we meticulously define the role of EMFs, diving into how they affect our health, discussing proactive protection measures, and sharing strategies for mitigating EMF exposure while traveling. We also explore how the revolutionary Somavedic device works, my experience using it, how to choose the correct model, the effects of structured water, and biohacking strategies that Juraj uses daily. Join us for an enriching conversation where we provide valuable insights and practical strategies to enhance your health. IN THIS EPISODE YOU WILL LEARN: What are EMFs? Juraj discusses the biological effects of chronic EMF exposure How to protect yourself from or minimize the impact of EMF exposure How to deal with EMF exposure when traveling Juraj explains how the Somavedic technology works What structured water is  Why it is beneficial for us to drink structured water Juraj discusses his daily health routine  Strategies for improving your health How to select the Somavedic device that best suits your needs Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Juraj Kocar On his website *Get a 10% discount on Somavedic products by using the code CYNTHIA (Discount code is valid all year long!) On Instagram Via email: hello@somavedic.com

20 Mar 202441min

Dr. Thomas Dayspring is certified in internal medicine and clinical lipidology. He is a fellow of the American College of Physicians and the National Lipid Association. He joins me today for the second class in our series of Lipid Masterclasses.   In today’s class, Dr. Dayspring shares valuable insights on cardiovascular health and lipid management. We dive into the complexities of cardiovascular disease, focusing on lipoproteins, atherogenesis progression, and its implications on myocardial infarctions (heart attacks). He explains the mechanisms of ApoB invasion into arterial walls and discusses the critical importance of finding competent healthcare providers, particularly for women navigating the perimenopausal to menopausal transition. He also gets into the limitations of bikini medicine, and we tackle pertinent issues surrounding hormone replacement therapy, including potential side effects and clinical observations.  Dr. Dayspring has a wealth of information to share today, and we have several additional masterclasses coming up to follow this class. Be sure to tune in for those episodes. IN THIS EPISODE YOU WILL LEARN: How lipids get transported, and how energy gets produced in the body How the liver prevents fatty liver tissue from building up Dr. Dayspring explains the process of lipolysis   What is the role of LDL particles in atherosclerosis? How the buildup of plaque in arteries can lead to blockages, causing heart attacks or strokes if left untreated Why high cholesterol needs to get diagnosed and treated as early as possible  The importance of HDL cholesterol in immunity and oncogenesis Why ApoB is essential for lipid panel analysis Why women need comprehensive medical care, especially during menopause Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com cynthiathurlow.com/lipids Connect with Dr. Thomas Dayspring Twitter (@DrLipid) LinkedIn

16 Mar 202450min

Today, I am delighted to reconnect with Dr. Sara Gottfried, a board-certified physician practicing evidence-based integrative precision and functional medicine. (She last joined me for Episode 211.) Dr. Gottfried graduated from Harvard and MIT. She is a Clinical Assistant Professor in the Department of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University and the Director of Precision Medicine at the Marcus Institute of Integrative Health. She is also the author of four New York Times best-selling books, including her recent publication, The Autoimmune Cure.  In our discussion today, we discuss the interrelationship between trauma and autoimmunity, highlighting its prevalence, particularly among women. We dive into the impact of trauma, explaining its correlation with autoimmune conditions and demystifying the role of the PINE network (the Psycho Immune Neuro Endocrine system). We explore triggers for perimenopause and menopause, gender differences specific to the changes in immunity and vulnerability in women, the consequences of burnout in various professions, the shortcomings of conventional allopathic methods in addressing mental health and trauma, and immunomodulation, including vitamins, polyphenols, low-dose Naltrexone, and somatic-based therapies.  With Dr. Gottfried’s invaluable insights into crucial health topics, this episode is a must-listen. Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: How the traumas we experience as children could make us more susceptible to autoimmune conditions later in life How trauma impacts our immune, neurological, and endocrine systems Addressing trauma through gut health, heart rate variability, and hormone balance How the metabolic and immune system changes triggered during perimenopause and menopause can make women more susceptible to autoimmune issues  How men in combat and women with sexual assault show similar trauma responses  How childhood trauma can shape our direction in life The potential benefits of alternative therapies like LSD, MDMA, and Ayahuasca How measuring gut health can provide valuable insights for treatment options Using low-dose Naltrexone for sleep and immune system modulation The potential of somatic therapies and breathwork for stilling the autonomic nervous system and promoting body awareness Bio: Dr. Sara Gottfried: Sara Szal Gottfried, MD, is a physician, researcher, author, and educator. She graduated from Harvard Medical School and MIT and completed a residency at UCSF, but is more likely to prescribe a CGM and personalized nutrition plan than the latest pharmaceutical. Dr. Gottfried is a global keynote speaker and the author of four New York Times bestselling books about hormones, nutrition, and health. Her latest book is called THE AUTOIMMUNE CURE (March 2024). She is a Clinical Assistant Professor in the Dept. of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University and Director of Precision Medicine at the Marcus Institute of Integrative Health. She takes care of executives and professional athletes. Her focus is on the interface of mental and physical health, N-of-1 trial design, personalized molecular profiling, use of wearables, and how to leverage these tools to improve health outcomes.  Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Sara Gottfried On her website    On Instagram Dr. Gottfried’s new book, The Autoimmune Cure, is available from most bookstores, including Amazon and Barnes and Noble. Previous Episode Mentioned Ep. 211 – Addressing the Root Cause of Hormonal Imbalances with Dr. Sara Gottfried

13 Mar 202455min

I am delighted and honored today to interview Dr. Lisa Mosconi. She is an Associate Professor of Neuroscience in neurology and radiology at Cornell Medicine and Director of the Women's BRAIN Initiative and the Alzheimer's Prevention Clinic at Weill Cornell Medicine, New York Presbyterian Hospital. She is also a globally acclaimed neuroscientist with a Ph.D. in neuroscience and nuclear medicine and the author of the New York Times bestseller The XX Brain and, more recently, The Menopause Brain. In our conversation, we discuss how women’s brains change during perimenopause and menopause, looking at the significance of puberty, pregnancy, and perimenopause, as well as the lack of medical research on women and medical gaslighting. We explore the concept of bikini medicine and its misconceptions regarding women's health and hormones alongside the crucial roles of hormones like estradiol, progesterone, and testosterone in our neuroendocrine system. Dr. Mosconi also provides insights into evolving menopausal treatments, including lifestyle interventions.  Dr. Mosconi is an esteemed figure in neuroscience and a prominent voice in women's health. I am confident you will gain valuable insights and perspectives from my discussion with her today. IN THIS EPISODE YOU WILL LEARN: How women's brains change during perimenopause and menopause How the lack of information for young girls can lead to medical gaslighting and confusion during perimenopause Dr. Mosconi explains how a simple sugar is used as a tracer to track glucose metabolism in the brain during perimenopause Why brain changes during menopause may lead to mental fatigue and brain fog How the lack of training and research on menopause in medical residency programs leads to a poor understanding among clinicians Why women need to consider their brain and metabolic health during perimenopause Why estrogen is essential after menopause The benefits of HRT for menopausal women How stress impacts hormone production Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Lisa Mosconi On her website On Instagram The Menopause Brain will be released March 12th, 2024.

9 Mar 202458min

Today's episode is a true gem! I am thrilled to introduce Craig Siegel, the Wall Street Journal and USA Today Best Selling Author of The Reinvention Formula. Craig is recognized globally as a keynote speaker, TEDx speaker, and host of the CLS Experience Podcast, where he has conversed with some of the most influential figures in the world. Having the privilege of being a guest on his show in 2023, I am delighted to have Craig joining me today to share his remarkable insights and discuss his inspiring journey.  In our conversation today, Craig shares how the pandemic became a catalyst for his evolution, which he refers to as his global awakening. We explore the importance of setting audacious goals and the transformative power of vulnerability. We also look into neuro-linguistic programming and clarify how it can cultivate confidence and reframe your mindset. We also discuss the role of adversity, ego dynamics, and why service implies love, and creates a lasting legacy. This conversation will infuse your year with invaluable wisdom, and I look forward to additional collaborations with Craig going forward.  Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: How the pandemic restructured Craig’s life and helped him redefine himself Craig shares his journey of embracing vulnerability and authenticity The benefits of having bold, fearless, and audacious goals How being willing to look silly or make mistakes can lead to success How mindset influences growth, both personally and professionally How neuro-linguistics can reprogram belief systems The power of choice and imagination for creating positive change Why it is essential to align your decisions with your personal and professional goals rather than being driven by ego Why building a community based on mutual support and collaboration is even more important than building an audience How authentic conversations can lead to inspired action Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com Connect with Craig Siegel On his website Instagram The CLS Experience Podcast Craig's Book The Reinvention Formula is available on Amazon and most anywhere books are sold. For free inspirational messages throughout the week, text Craig at 917-634-3796 using the code CYNTHIA and share your favorite nugget from today’s conversation.

6 Mar 202451min

Today, I am delighted to reconnect with two previous guests, Dr. Darren Candow. Dr. Candow is a distinguished professor and an internationally renowned researcher on creatine monohydrate, nutrition, and physical activity who joined me before on Episode 301, where we spoke about creatine.  We are doing an AMA session today, delving into various themes surrounding creatine, from debunking outdated RDA recommendations to exploring the synergies between strength training and creatine efficacy. We look into the cognitive benefits of creatine, exploring how it interacts with caffeine and its implications for bone health, hydration, anabolic resistance, and metabolic health.  I trust you will find today's AMA session as enlightening and enriching as I did while recording it. IN THIS EPISODE YOU WILL LEARN: The safety and efficacy of creatine as a supplement How creatine increases muscle mass and reduces protein catabolism The benefits of combining creatine with protein  Is it better to take creatine before or after a workout? How creatine supplementation may improve brain performance and mental clarity Why exercise is essential for those who want to experience the benefits of creatine for maintaining their bone health The benefits of resistance-band workouts for post-menopausal women Are there any age-related limits for creatine supplementation? Bio: Dr. Darren Candow Dr. Darren Candow, PhD, CSEP-CEP, is Professor and Director of the Aging Muscle and Bone Health Laboratory in the Faculty of Kinesiology and Health Studies at the University of Regina, Canada. The overall objectives of Dr. Candow’s research program are to develop effective lifestyle interventions involving nutrition (primarily creatine monohydrate) and physical activity (resistance training), which have practical and clinical relevance for improving musculoskeletal aging and reducing the risk of falls and fractures. Dr. Candow has published over 120 peer-refereed journal manuscripts, supervised over 20 MSc and PhD students, and received research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, the National Institute of Health, and the Nutricia Research Foundation. In addition, Dr. Candow serves on the editorial review boards for the Journal of the International Society of Sports Nutrition, Nutrients, and Frontiers. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Darren Candow On Instagram and Twitter (now X) Previous Episode Mentioned: Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Darren Candow, PhD, CSEP-CEP

2 Mar 202453min