Questioning Medicine16 Mai 2024

Episode 288: 287. A New FDA Approved Drug for Chronic Rhinosinusitis

recipients were more likely than placebo recipients to report much or very much improvement (55% vs. 25%) which isn’t shocking because half of the people were not getting medicine

they also report that the medication arm had improvement on CT imaging of the sinuses which also seems like another Duh moment as I am sure it was better than nothing

my concern is this new drug or deliver of the drug is a cash price of about 800-1000 per month while just simple fluticasone is around 10$ a month. I think for now stick with the normal 10$ fluticasone but if there is no success and continue to have severe symptoms then maybe consider this if they have good insurance

bottom line is there is a new drug out there that is basically fluticasone in a fancy delivery device.. for almost all my patients and family members they will be getting regular fluticasone not this fancy delivery device that goes but the name XHANCE

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S221321982301365X?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221321982301365X%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.jwatch.org%2F

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Episoder(397)

Episode 435: 442. 7 article review

we unpack whether rivaroxaban followed by aspirin improves thromboprophylaxis after hip and knee arthroplasty, put oral GLP-1 therapy orforglipron head-to-head with dapagliflozin for type 2 diabetes, ...

10 Sep 33min

Episode 434: 441. Coronary Artery Calcium (CAC) -- Yacky Yack, the details on CAC

Does a Coronary Artery Calcium (CAC) scan still earn its place in modern cardiovascular prevention? This podcast cuts through the headlines to examine the recent research, challenge overconfident conc...

31 Aug 48min

Episode 433: 440. CME Understanding Medical Stats

OMED lecture on how to understand medical stats

21 Aug 33min

Episode 432: 439. 6 articles in 2026

CME

24 Jul 25min

Episode 431: 438. CME- What To Do AFTER PE Diagnosis

OMED lecture

21 Jul 26min

Episode 430: edit fix 437. A Brief Review of the Medical Literature!

Xin X, et al. Optimal exercise modalities and dosages for blood pressure reduction in adults with prehypertension and established hypertension: A network meta-analysis and dose–response relationship s...

8 Jul 32min

Episode 429: 436. postpartum burnout., asundexian, semaglutide and ETOH, neck infection, varenicline

Jafari K, et al. Risk factors for pediatric deep neck infection revisit after emergency department discharge for pharyngitis or localized neck symptoms. Ann Emerg Med 2026 May; 87:605. DOI: 10.1016/j....

15 Jun 31min

Episode 428: 435. Evolocumab, Statin and CKD, PCN allergy, MRI vs Rotator Cuff

https://pubmed.ncbi.nlm.nih.gov/41903215/ Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV ...

8 Mai 17min