Episode 301: 300. A New Trial On Beta Blockers and COPD

Episode 301: 300. A New Trial On Beta Blockers and COPD

The problems with observation data is real—

randomized trial, U.K. researchers identified 519 patients (mean age, 68) with mostly moderate COPD (mean forced expiratory volume in 1 second [FEV1], 50%), ≥2 exacerbations during the previous year, and no cardiovascular (CV) indications for β-blockers.

Patients were randomized to receive the cardioselective β-blocker bisoprolol (initially 1.25 mg daily, titrated to 5 mg if tolerated) or placebo.

At 1 year, no significant differences were noted between groups in incidence of COPD exacerbations or in other important benefits or harms.



Cardioselective β-blockers remain appropriate for COPD patients who have valid cardiovascular indications for their use, but taken these two studies together suggests that COPD patients without such indications should avoid bblockers—even cardio selective beta blockers

https://jamanetwork.com/journals/jama/article-abstract/2819083

Episoder(385)

Episode 367: 378. What is the Best Way To Treat Ductal Carcinoma In Situ

Episode 367: 378. What is the Best Way To Treat Ductal Carcinoma In Situ

https://jamanetwork.com/journals/jama/article-abstract/2828218DCIS is a non-invasive form of breast cancer, meaning the abnormal cells are contained within the milk ducts. For years, the standard trea...

12 Feb 20258min

Episode 366: 377. Does How Long You Have Hypertension Matter?

Episode 366: 377. Does How Long You Have Hypertension Matter?

Association of Duration of Recognized Hypertension and Stroke Risk: The REGARDS Study   (Transition Music - Short and subtle - 2 seconds)Host:  Hypertension is a well-known risk factor for stroke, but...

11 Feb 20257min

Episode 365: 366. Association of dose of inhaled corticosteroids and frequency of adverse events

Episode 365: 366. Association of dose of inhaled corticosteroids and frequency of adverse events

Bloom CI et al. Association of dose of inhaled corticosteroids and frequency of adverse events. Am J Respir Crit Care Med 2025 Jan; 211:54. (https://doi.org/10.1164/rccm.202402-0368OC)  Bloom and coll...

7 Feb 20256min

Episode 364: 364. The safety and efficacy of sodium–glucose cotransporter 2 inhibitor in hospitalized patients

Episode 364: 364. The safety and efficacy of sodium–glucose cotransporter 2 inhibitor in hospitalized patients

Gao FM et al. A systematic review and meta-analysis on the safety and efficacy of sodium–glucose cotransporter 2 inhibitor use in hospitalized patients. Diabetes Care 2024 Dec 1; 47:2275. (https://doi...

4 Feb 20257min

Episode 363: 262. Myocardial injury in patients with hip fracture

Episode 363: 262. Myocardial injury in patients with hip fracture

Is accelerated surgery for hip fracture better for high-risk patients? A recent substudy of the HIP ATTACK trial has shed new light on this topic. The original trial, published in 2020, compared accel...

31 Jan 20255min

Episode 362: 261. What to do with the beta blocker following a Myocardial Infarction

Episode 362: 261. What to do with the beta blocker following a Myocardial Infarction

Today, we're discussing two groundbreaking studies from 2024 that challenge our understanding of β-blocker therapy for secondary prevention after myocardial infarction, or MI.Let's start with a Swedis...

15 Jan 20256min

Episode 361: 260. METHODS MONDAY-- EVENT RATE

Episode 361: 260. METHODS MONDAY-- EVENT RATE

Methods Monday  --- Accuracy of Event Rate and Effect Size Estimation in Major Cardiovascular Trials: A Systematic Review | Cardiology | JAMA Network Open | JAMA Network  During the design of a random...

13 Jan 202510min

Episode 360: 259. Urinary Retention Evaluation and Catheterization Algorithm for Adult Inpatients

Episode 360: 259. Urinary Retention Evaluation and Catheterization Algorithm for Adult Inpatients

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821168A team of researchers set out to change that by developing a comprehensive algorithm.The process involved a multidisciplinary panel ...

10 Jan 20257min

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