Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

Episode 222: 222. Ablation for AFIB in patients with HFrEF

Episode 222: 222. Ablation for AFIB in patients with HFrEF

Consider ablation in patients who have an EF < 35% and atrial fibrillation the NNT for all cause mortality was 7 at 18 months https://www.nejm.org/doi/full/10.1056/NEJMoa2306037

19 Jan 20244min

Episode 221: 221. Nurse Led Sleep Restriction IMPROVES Insomnia

Episode 221: 221. Nurse Led Sleep Restriction IMPROVES Insomnia

Sleep restriction therapy led by nurses with only 4 hours of education significantly improved patients insomnia at 6 months. More info HERE ___>https://thrive.kaiserpermanente.org/care-near-you/northe...

18 Jan 20246min

Episode 220: 220. Semaglutide at 1yr Gives Small Improvement in Questionnaire for those with HFpEF

Episode 220: 220. Semaglutide at 1yr Gives Small Improvement in Questionnaire for those with HFpEF

Kansas City Cardiomyopathy Questionnaire clinical summary score was improved by 7.8 in those individuals with HFpEF that took semaglutide for one year compared to those that took placebo. This is a sm...

17 Jan 20245min

Episode 219: 219. Oral Iron better with vitamin C  on an empty stomach

Episode 219: 219. Oral Iron better with vitamin C on an empty stomach

When taking Ferrous Fumarate a little bit of vitamin C or an 8 ounce glass of orange juice with an otherwise empty stomach will improve the absorption- this absorption is decreased with food and coffe...

16 Jan 20245min

Episode 218: 218. Semaglutide and CAD But No Diabetes - Decrease Event$$$$$$

Episode 218: 218. Semaglutide and CAD But No Diabetes - Decrease Event$$$$$$

https://www.nejm.org/doi/full/10.1056/NEJMoa2307563Semaglutide and CAD but no diabetes decreases events NNT of 66 at 40 months but a predicted price tag of 3.5 million dollars.

12 Jan 20247min

Episode 217: 217. Olanzapine 2.5mg for weight gain with advance cancer

Episode 217: 217. Olanzapine 2.5mg for weight gain with advance cancer

Olanzapine 2.5mg for weight gain with advance cancer NNT of 50 for >5% weight gainhttps://pubmed.ncbi.nlm.nih.gov/36977285/

11 Jan 20245min

Episode 216: 216. AFIB- RATE or ABLATE-- New guidelines

Episode 216: 216. AFIB- RATE or ABLATE-- New guidelines

ACC/AHA just came out with new guidelines on AFIB if you need some light reading material! (big take home rhythm not rate, and not equal, read below for more information) A HUGE piece of new is that n...

27 Des 20239min

Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?

Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?

Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial | Clinical Pharmacy and Pharmaco...

20 Des 20234min

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