Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(386)

Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?

Episode 215: 215. Enteric coated or uncoated aspirin, which is better or safer?

Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial | Clinical Pharmacy and Pharmaco...

20 Des 20234min

Episode 214: 214. NEW FORMAT-- What is the best drug for alcohol use disorder?

Episode 214: 214. NEW FORMAT-- What is the best drug for alcohol use disorder?

214. NEW FORMAT-- What is the best drunk for alcohol use disorder?https://jamanetwork.com/journals/jama/article-abstract/2811435

15 Des 20239min

Episode 213: 213. Heart Failure CME lecture

Episode 213: 213. Heart Failure CME lecture

systolic

8 Des 202344min

Episode 212: 212. Stroke and TIA management and update

Episode 212: 212. Stroke and TIA management and update

CME for the cost of free fifty free

8 Des 202340min

Episode 211: 211. Pharmacogenomics Testing, PHASER,

Episode 211: 211. Pharmacogenomics Testing, PHASER,

(https://www.healthquality.va.gov/guidelines/MH/mdd/VADoDMDDCPGFinal508.pdf) clearly state there is insufficient evidence to support this activity and testing. This is mainly because of low quality ev...

12 Jul 202327min

Episode 210: 210. An Evidence Based Update for Hospitalist

Episode 210: 210. An Evidence Based Update for Hospitalist

I give CME and you listen for free. You can't collect the CME but YOU CAN be a little smarter. These are some must know articles you need to know if you are a hospitalist.

27 Jun 202336min

Episode 209: 209. Medical Update -- kidney stones, statins, iron, heart failure, vitamin D

Episode 209: 209. Medical Update -- kidney stones, statins, iron, heart failure, vitamin D

What about oral?? Lewis GD et al. Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency: The IRONOUT HF randomized clinic...

7 Jun 202358min

Episode 208: 208. Medical Update- VIP medicine, Pre-Diabetes, Prevent food allergies, PRP

Episode 208: 208. Medical Update- VIP medicine, Pre-Diabetes, Prevent food allergies, PRP

Lindholt JS, Søgaard R, Rasmussen LM, et al. Five-year outcomes of the Danish cardiovascular screening (DANCAVAS) trial. N Engl J Med 2022;387(15):1385-1394.  Study design: Randomized controlled trial...

2 Mai 202319min

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