Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

Episode 206: 206. Testosterone Replacement Therapy

Episode 206: 206. Testosterone Replacement Therapy

YES!! Marketing!! No man wants to admit his gonads dont work so they would never say I have hypogonadism. Most men would never say I have andropause cause that is too close to menopause but if you cal...

25 Nov 202222min

Episode 205: 205. Medical Update

Episode 205: 205. Medical Update

coffee saves your life-- maybe, careful for confounders heart failure hospital admission is really hard to preventmoderate dose statin is most important..but ezetmibe and moderate dose is equal to hig...

14 Nov 202225min

Episode 204: 204. Medical Update- skin exam, ddp4, IUD, oral hypertension medication

Episode 204: 204. Medical Update- skin exam, ddp4, IUD, oral hypertension medication

skin exam, ddp4, IUD, oral hypertension medication

18 Sep 202223min

Episode 203: 203. Medical Update 203 -- HEAD CT, Weekend warrior, REDUCE-IT, SGLT-2, HF, DMARD, Blood test

Episode 203: 203. Medical Update 203 -- HEAD CT, Weekend warrior, REDUCE-IT, SGLT-2, HF, DMARD, Blood test

https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.059410?af=RThe Biomarkers say REDUCE-IT was a scamhttps://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2791663NO! Just ...

1 Sep 202228min

Episode 202: 202. repost mammograms part 2

Episode 202: 202. repost mammograms part 2

mammograms and pink ribbons-- lets talk evidence

29 Aug 202222min

Episode 201: 201. repost mammograms part 1

Episode 201: 201. repost mammograms part 1

mammograms-- we all know them, but lets discuss

25 Aug 202220min

Episode 200: 200. COVID 4th Vaccine, Vitamin D, Statin

Episode 200: 200. COVID 4th Vaccine, Vitamin D, Statin

Association of Receipt of the Fourth BNT162b2 Dose With Omicron Infection and COVID-19 Hospitalizations Among Residents of Long-term Care Facilities | Geriatrics | JAMA Internal Medicine | JAMA Networ...

17 Aug 202231min

Episode 199: 199. weight gain semaglutide, Asthma, olive oil, Hypertension in pregnancy

Episode 199: 199. weight gain semaglutide, Asthma, olive oil, Hypertension in pregnancy

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension - Wilding - - Diabetes, Obesity and Metabolism - Wiley Online Library   “”””One year after withdra...

29 Jul 202218min

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