Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

143. Dexa Scans, Atypical Fractures, Cervical CA Screening, Capsaicin intraarticular

143. Dexa Scans, Atypical Fractures, Cervical CA Screening, Capsaicin intraarticular

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2768888Serial Bone Density Measurement and Incident Fracture Risk Discrimination in Postmenopausal WomenCarolyn J. Crandall, MD, MS1; ...

26 Aug 202023min

142. Covid, Appendicitis, COPD, Vitamin D

142. Covid, Appendicitis, COPD, Vitamin D

Sometime I wonder how the world will change post covid- or how the board questions will change? And that is clearly seen in this article titled- Yip L et al. Serious adverse health events, including d...

19 Aug 202023min

141. Primary Care Burnout! TSH, Viagra, Hepatitis C screening and SGLT2 vs DDP4

141. Primary Care Burnout! TSH, Viagra, Hepatitis C screening and SGLT2 vs DDP4

henry ford once said “failure is simply the opportunity to begin again, this time more intelligently”Designed to Fail? the Future of Primary CareJournal of General Internal Medicine (2020) Access to p...

11 Aug 202020min

 140. #Medbikini, Is vascular surgery unprofessional on social media??

140. #Medbikini, Is vascular surgery unprofessional on social media??

https://twitter.com/NarducciDusty/status/1290044202852614145?s=20

5 Aug 20208min

139. COVID19, Mask, Kids, and More Terrible Studies

139. COVID19, Mask, Kids, and More Terrible Studies

Characteristics and Strength of Evidenceof COVID-19 Studies Registeredon ClinicalTrials.gov Looked at ClinicalTrials.gov identified 1551 studies registered fromMarch 1, 2011, to May 19, 2020,Lets look...

31 Jul 202027min

138. Autism Screening, Tobacco-Dependent Treatment, HIV Treatment, Apixaban vs Enoxaparin

138. Autism Screening, Tobacco-Dependent Treatment, HIV Treatment, Apixaban vs Enoxaparin

Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guidelinehttps://www.atsjournals.org/doi/full/10.1164/rccm.202005-1982STultimate...

22 Jul 202022min

137. Antibiotics in Children, TSH, Hip Osteoarthritis, Mammograms

137. Antibiotics in Children, TSH, Hip Osteoarthritis, Mammograms

https://www.youtube.com/watch?v=EBhEjYhVoZkGoggin K et al. Reductions in parent interest in receiving antibiotics following a 90-second video intervention in outpatient pediatric clinics. J Pediatr 20...

16 Jul 202022min

136. Elderly Statins, Alcohol Dependence in PCP, Cancer Screening,

136. Elderly Statins, Alcohol Dependence in PCP, Cancer Screening,

Orkaby AR et al. Association of statin use with all-cause and cardiovascular mortality in US veterans 75 years and older. JAMA 2020 Jul 7; 324:68. (https://doi.org/10.1001/jama.2020.7848) retrospectiv...

10 Jul 202025min

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