Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

134. COVID19, Dexamethasone, Chlorthalidone vs Hydrochlorothiazide

134. COVID19, Dexamethasone, Chlorthalidone vs Hydrochlorothiazide

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133. Effectiveness of Adenotonsillectomy, FDA and albuterol, Anti-Coag and hemodialysis, Tanning and Money

133. Effectiveness of Adenotonsillectomy, FDA and albuterol, Anti-Coag and hemodialysis, Tanning and Money

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792273/Does Rewording MRI Reports Improve Patient Understanding and Emotional Response to a Clinical Report?Remember few weeks ago when I talked about 50%...

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132. COVID, Hydroxychloroquine, Afib Ablation, Influenza Vaccine Notification

132. COVID, Hydroxychloroquine, Afib Ablation, Influenza Vaccine Notification

Covid infohttps://melwy.com/blog/lancet-paper-on-chloroquine-is-overhyped-real-world-data-should-not-be-a-black-box So I couldn’t miss the largest observational study published to date on the effect...

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131. Prostate, COVID, Women Pay Gap

131. Prostate, COVID, Women Pay Gap

Prostate Cancer Incidence 5 Years After US Preventive Services Task Force Recommendations Against Screening JNCI: Journal of the National Cancer Institute, djaa068,——Published: 20 May 2020https://jama...

28 Mai 202027min

130. Antibiotics, BIOTOK and Knee Osteoarthritis, and Bempedoic Acid

130. Antibiotics, BIOTOK and Knee Osteoarthritis, and Bempedoic Acid

Fox MT et al. Comparative effectiveness of antibiotic treatment duration in children with pyelonephritis. JAMA Netw vOpen 2020 May 1; 3:e203951. (https://doi.org/10.1001/jamanetworkopen.2020.3951) Rat...

19 Mai 202024min

129. Chronic Kidney Disease, Cholesterol LDL, Urinary Antigen Testing, Gout, Pharmaceutical Industry,

129. Chronic Kidney Disease, Cholesterol LDL, Urinary Antigen Testing, Gout, Pharmaceutical Industry,

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2762699Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estim...

12 Mai 202020min

128. COVID, Coronavirus, When will it end? The Answer...

128. COVID, Coronavirus, When will it end? The Answer...

https://science.sciencemag.org/content/early/2020/04/24/science.abb5793read an interesting paper title- Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science 14 A...

4 Mai 202026min

127. Guidelines, COVID, Econsults, COVID19, CDC

127. Guidelines, COVID, Econsults, COVID19, CDC

https://covid19treatmentguidelines.nih.gov/A National Institutes of Health panel has released new guidelinesagainst use of hydroxychloroquine plus azithromycin outside of clinical trials https://www.n...

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