Big Brains3 Apr 2025

Can You Really Die of a Broken Heart? The Hidden Dangers of Grief, with Mary Frances O'Connor

When we lose someone, we love, we often say we have a broken heart—but what if that’s not just a metaphor?

In her new book “The Grieving Body: How The Stress of Loss Can Be An Opportunity For Healing” University of Arizona Professor of Psychology Mary Frances O’Connor shares groundbreaking insights into the biological and physiological impacts grief has on our bodies. O’Connor reveals how profound loss can lead to serious medical conditions, from heart attacks to immune system breakdowns, and explains why grieving can make us more vulnerable to diseases like cancer, pneumonia, and even autoimmune disorders.

Drawing on her personal experiences and extensive research, O’Connor outlines why our medical system—and society at large—needs to rethink how we support grieving individuals. She makes a powerful case for viewing grief not only as an emotional experience but as a medical event deserving careful monitoring and intervention, similar to pregnancy or chronic illness.

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