Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

Moderator: Jean-Marc Burgunder (Guemligen, Switzerland)Guest: Sandrine Humbert (Paris, France)In this week's episode, Burgunder and Humbert discuss the intriguing phenomenon of somatic expansion—the further increase of CAG repeat numbers in the gene involved in Huntington’s disease, particularly in the striatum. They explore the molecular mechanisms behind this process, as addressed in two recent research papers.Please find here the papers discussed in this episode: Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s diseaseand Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely aleady an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department (membership@ean.org) to cross-check if you are listed as an Associate Member to get access to eanCampus.

Episoder(192)

Ep. 152: Breaking the Burnout Cycle: EAN and EPA Collaboration

Ep. 152: Breaking the Burnout Cycle: EAN and EPA Collaboration

In this episode González Martinez together with Toscano and Toparlak explores how collaboration between neurology and psychiatry helps combat clinician burnout, highlighting insights from the EAN Task...

15 Jun 202524min

Ep. 151: Burnout in Neurology: Real Cases and Practical Lessons

Ep. 151: Burnout in Neurology: Real Cases and Practical Lessons

In this episode, Accorroni, Grneva, and de Visser explore burnout in neurology through real-life stories and insights. They discuss its impact across career stages, key causes like workload and gender...

8 Jun 202527min

Ep. 150: Is Burnout a Mental Disorder? Insights from Neurology and Psychiatry

Ep. 150: Is Burnout a Mental Disorder? Insights from Neurology and Psychiatry

In this thought-provoking episode di Liberto is joined by Cuffaro and Gurrea Salas as they explore the complex question: Is burnout a mental disorder? and bring cross-disciplinary insights from their ...

3 Jun 202526min

Ep. 149: Normal pressure hydrocephalus

Ep. 149: Normal pressure hydrocephalus

Moderator: Marian Galovic (Zurich, Switzerland) Guest: Per Kristian Eide (Oslo, Norway) In this episode, moderator Marian Galovich and guest Per Kristian Eide delve into the often overlooked but high...

25 Mai 202526min

Ep. 148: Ultrasound-Guided Botulinum Toxin Injection in Dystonia

Ep. 148: Ultrasound-Guided Botulinum Toxin Injection in Dystonia

Moderator: Nihat Mustafayev (Istanbul, Türkiye) Guest: Dr Anna Castagna (Milano, Italy) This episode explains how ultrasound-guided botulinum toxin injections are performed in patients with dystoni...

18 Mai 202521min

Ep. 147: Basic Immunology in Rare CNS Disorders

Ep. 147: Basic Immunology in Rare CNS Disorders

Moderator: Gianmarco Abbadessa (Naples, Italy) Guest: Heinz Wiendl (Muenster, Germany) In this episode, Abbadessa and Wiendl delve into the pathogenesis and pathophysiology of rare CNS autoimmune dis...

11 Mai 202531min

Ep. 146: Importance of brain donation in neurodegenerative diseases

Ep. 146: Importance of brain donation in neurodegenerative diseases

Ean Moderator: Yıldız Değirmenci (Istanbul, Türkiye) Guest: Didem Öz (Izmir, Türkiye) In this episode, Değirmenci and Öz discuss the vital importance of brain donation in understanding and treating...

4 Mai 202527min

Ep. 145: Why Should Neurologists Care About the World Dance Day?

Ep. 145: Why Should Neurologists Care About the World Dance Day?

Moderator: Alicia Gonzalez Martinez (Madrid, Spain) Guests: Thomas Berger (Vienna, Austria), Julia Polai (Innsbruck, Austria) In this episode for World Dance Day, Gonzales Martinez discusses the phys...

27 Apr 202520min

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