275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

Gene therapy is rapidly emerging as a transformative approach for treating genetic hearing loss, with Regeneron advancing one of the field’s most promising candidates: DB-OTO. In this conversation, Regeneron's Auditory Global Program Head Dr. Jonathon Whitton provides an in-depth look at the company’s work developing a gene therapy targeting otoferlin-related hearing loss, a rare but significant condition causing congenital deafness in children. Whitton explains the scientific rationale behind targeting the OTOF gene, the challenges of delivering gene therapy to the inner ear, and why this therapy holds particular promise for pediatric patients. He also discusses how Regeneron is designing clinical trials with long-term outcomes in mind, as well as the broader implications for treating other forms of genetic hearing loss. This discussion offers valuable insights into the future of hearing therapeutics and the role large biotech companies may play in making genetic treatments more accessible.


The following Regeneron pages highlight the company’s research on gene therapies for hearing loss and provide information on genetic testing and navigating a hearing loss diagnosis:

  • https://aboutgenetichearingloss.com
  • https://www.regeneron.com/stories/auditory-gene-therapy

Be sure to subscribe to our channel for the latest episodes each week and follow This Week in Hearing on LinkedIn and X (formerly Twitter).- https://twitter.com/WeekinHearing- https://www.linkedin.com/company/this-week-in-hearing- https://hearinghealthmatters.org/thisweek/

Episoder(351)

327 - From Ambivalence to Action: Rethinking Patient Counseling in Hearing Care

327 - From Ambivalence to Action: Rethinking Patient Counseling in Hearing Care

Why do so many people delay hearing care—even after acknowledging a problem or receiving a recommendation? In this conversation, hearing instrument specialist and researcher Bobbi-Jo Marlatt explores ...

20 Jan 24min

326 - Can Auracast Redefine Audio Accessibility in Public Spaces?

326 - Can Auracast Redefine Audio Accessibility in Public Spaces?

What will it take for accessible audio to become the norm rather than the exception in public spaces? In this conversation, Andrew Bellavia is joined by Paul Daft of GN and journalist and accessibilit...

12 Jan 55min

325 - Giants of Audiology: Interview with Richard W. Danielson, PhD

325 - Giants of Audiology: Interview with Richard W. Danielson, PhD

Dr. Richard W. “Dick” Danielson’s career in audiology spans decades of service, leadership, and innovation across the U.S. Army, academic medicine, and NASA. A retired Army Colonel and former manager ...

26 Des 20251h 4min

324 - Auracast in Action: Exploring Hearing Accessibility in a Busy Railway Station

324 - Auracast in Action: Exploring Hearing Accessibility in a Busy Railway Station

What does accessible audio look like when it’s designed for real-world environments—not just controlled settings? In this conversation, Jonathan Hoskin of Ampetronic explains how Auracast was deployed...

17 Des 202533min

323 - How Hearing Aid Innovation Happens: Jason Galster on Turning Research Into Real-World Technology

323 - How Hearing Aid Innovation Happens: Jason Galster on Turning Research Into Real-World Technology

Where do the best ideas in hearing aid innovation come from, and how do they reach patients? In this conversation, Dr. Jason Galster, Vice President of Clinical Research at Sonova, explains how hearin...

12 Des 202526min

322 - Widex Allure Expands With BTE, Rechargeable ITE, Portable Charging & Software Updates

322 - Widex Allure Expands With BTE, Rechargeable ITE, Portable Charging & Software Updates

Widex has expanded its Allure™ hearing aid platform with new form factors and charging options, giving hearing care professionals more flexibility across a wider range of patient needs. In this discus...

9 Des 202528min

321 - Life With a Fully Implanted Cochlear Implant: Michael Seufer Shares His Experience

321 - Life With a Fully Implanted Cochlear Implant: Michael Seufer Shares His Experience

A fully implantable cochlear implant isn’t just a technical milestone—it's a fundamentally different way of living with hearing loss. In a candid conversation, Gael Hannan speaks with Michael Seufer, ...

2 Des 202525min

320 - Exploring the H1 Hearing Buds: LXE’s Entry Into Earbud-Style OTC Hearing Aids

320 - Exploring the H1 Hearing Buds: LXE’s Entry Into Earbud-Style OTC Hearing Aids

A growing number of people are exploring hearing help earlier, and LXE Hearing believes there is a place for devices that bridge the gap between everyday earbuds and traditional hearing aids. In a det...

24 Nov 202528min

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