275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

275 - Inside Regeneron’s Groundbreaking Hearing Loss Gene Therapy Treatment Program

Gene therapy is rapidly emerging as a transformative approach for treating genetic hearing loss, with Regeneron advancing one of the field’s most promising candidates: DB-OTO. In this conversation, Regeneron's Auditory Global Program Head Dr. Jonathon Whitton provides an in-depth look at the company’s work developing a gene therapy targeting otoferlin-related hearing loss, a rare but significant condition causing congenital deafness in children. Whitton explains the scientific rationale behind targeting the OTOF gene, the challenges of delivering gene therapy to the inner ear, and why this therapy holds particular promise for pediatric patients. He also discusses how Regeneron is designing clinical trials with long-term outcomes in mind, as well as the broader implications for treating other forms of genetic hearing loss. This discussion offers valuable insights into the future of hearing therapeutics and the role large biotech companies may play in making genetic treatments more accessible.


The following Regeneron pages highlight the company’s research on gene therapies for hearing loss and provide information on genetic testing and navigating a hearing loss diagnosis:

  • https://aboutgenetichearingloss.com
  • https://www.regeneron.com/stories/auditory-gene-therapy

Be sure to subscribe to our channel for the latest episodes each week and follow This Week in Hearing on LinkedIn and X (formerly Twitter).- https://twitter.com/WeekinHearing- https://www.linkedin.com/company/this-week-in-hearing- https://hearinghealthmatters.org/thisweek/

Episoder(351)

319 - Lineage and William Demant Invest Partner to Advance Cell Therapy for Hearing Loss

319 - Lineage and William Demant Invest Partner to Advance Cell Therapy for Hearing Loss

Can lost hearing cells be replaced? Lineage Cell Therapeutics CEO Brian Culley returns to discuss the company’s new collaboration with William Demant Invest. Together, they’re advancing ReSonance™ (AN...

17 Nov 202513min

318 - Understanding Hearing Loss Stigma — What New Research Reveals

318 - Understanding Hearing Loss Stigma — What New Research Reveals

Hearing loss stigma continues to be one of the biggest barriers to seeking help — even as awareness and technology improve. In this discussion, host Shari Eberts speaks with Dr. Katie Ekberg (Flinders...

12 Nov 202527min

317 - Phonak Infinio Ultra Hearing Aids Combine AI Sound and Easy Maintenance

317 - Phonak Infinio Ultra Hearing Aids Combine AI Sound and Easy Maintenance

At EUHA 2025, Phonak presented the latest advancements to its Infinio platform, including the Virto R Infinio custom rechargeable hearing aid and the new Infinio Sphere Ultra upgrade. In a discussion ...

6 Nov 202524min

316 - Oticon Zeal Hearing Aids Bring AI Sound Processing to a Compact In-the-Ear Design

316 - Oticon Zeal Hearing Aids Bring AI Sound Processing to a Compact In-the-Ear Design

At EUHA 2025, Oticon introduced its newest in-the-ear hearing aid, Oticon Zeal, bringing the company’s second-generation AI sound processing and BrainHearing™ technology to a smaller, ready-to-fit for...

5 Nov 202512min

315 - Exploring Starkey’s Omega AI Hearing Aids: A Conversation with CTO Achin Bhowmik

315 - Exploring Starkey’s Omega AI Hearing Aids: A Conversation with CTO Achin Bhowmik

Earlier this month, Starkey released its Omega AI hearing aid platform, and at EUHA 2025, Chief Technology Officer Achin Bhowmik discussed how the company’s latest generation builds on prior AI-driven...

31 Okt 202525min

314 - Aaron Small and Robin Gillon Talk Hearing Loss, Confidence, and the Power of Connection

314 - Aaron Small and Robin Gillon Talk Hearing Loss, Confidence, and the Power of Connection

Andrew Bellavia joined Phonak ambassadors — Olympian Aaron Small and pro skier Robin Gillon — on stage to share honest conversations about hearing loss, stigma, and the role technology plays in stayin...

30 Okt 202516min

313 - Rethinking Preschool Hearing Screening: An Evidence-Based Approach with Dr. James W. Hall

313 - Rethinking Preschool Hearing Screening: An Evidence-Based Approach with Dr. James W. Hall

Early detection of hearing loss shouldn’t stop at birth. In this episode, Dr. Bob Traynor speaks with Dr. James W. Hall III, an internationally recognized audiologist, educator, and author with more t...

24 Okt 202528min

312 - Inside Audien’s Atom X Hearing Aids: CEO Ishan Patel Talks Innovation and Accessibility

312 - Inside Audien’s Atom X Hearing Aids: CEO Ishan Patel Talks Innovation and Accessibility

With the Atom X, Audien introduces a new touchscreen-based hearing aid designed for simplicity and accessibility. Andy Bellavia speaks with Audien Hearing CEO Ishan Patel about the device’s key featur...

23 Okt 202536min

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