Lead: The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies

Lead: The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies

The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies

Psychological Medicine

Using data from the EU-GEI case-control study and UK Biobank, researchers examined the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS), on risk for psychosis. Schizophrenia PRS and cannabis use independently increased risk of psychosis. Schizophrenia PRS was not associated with patterns of cannabis use. It was associated with lifetime and daily cannabis use without psychosis, but the effect was substantially reduced when cannabis use disorder (CUD) PRS was included in the model. Regular users of high-potency cannabis had the highest odds of being a case independently of schizophrenia PRS. Regular use of high-potency cannabis remains a strong predictor of psychotic disorder, independent of schizophrenia PRS. Schizophrenia PRS does not seem to be associated with heavy cannabis use. These are important findings, at a time of increasing use and potency of cannabis worldwide.

Read this issue of the ASAM Weekly

Subscribe to the ASAM Weekly

Visit ASAM

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(100)

Lead: Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study

Lead: Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study

Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study Addiction Adolescent past-year cannabis use trends ha...

29 Sep 7min

Lead: Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024

Lead: Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024

Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024 JAMA Network Open This retrospective cohort study examined characteristics associated with abandonment of newly prescribed bu...

22 Sep 8min

Lead: US drug overdose deaths involving stimulants without opioids continued to rise in 2024

Lead: US drug overdose deaths involving stimulants without opioids continued to rise in 2024

US drug overdose deaths involving stimulants without opioids continued to rise in 2024 Addictive Behaviors Reports Drug overdose deaths (DOD) peaked in 2022 before a decline in rates driven by decreas...

15 Sep 7min

Lead: US drug overdose deaths that occurred in isolation, 2022–2024

Lead: US drug overdose deaths that occurred in isolation, 2022–2024

US drug overdose deaths that occurred in isolation, 2022–2024 NEJM Evidence Data were obtained from SUDORS (State Unintentional Drug Overdose Reporting System) for 2022-2024. Of 191,577 overdose death...

9 Sep 7min

Lead: Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians

Lead: Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians

Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians Journal of the American Medical Association This Special Communication summarizes the evidence on the use ...

3 Sep 7min

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial The American Journal of Psychiatry Accumulating preclinical and observational evidence suggests that glucagon-like peptide-1 rece...

25 Aug 7min

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic Journal of Substance Use and Addiction Treatment This is an ...

18 Aug 7min

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction Cocaine use disorder (CUD) is an increasingly wi...

11 Aug 7min

Populært innen Politikk og nyheter

giver-og-gjengen-vg
aftenpodden
forklart
aftenpodden-usa
popradet
fotballpodden-2
stopp-verden
dine-penger-pengeradet
det-store-bildet
rss-espen-lee-usensurert
rss-gukild-johaug
saken
nokon-ma-ga
hanna-de-heldige
aftenbla-bla
rss-ness
rss-penger-polser-og-politikk
e24-podden
bt-dokumentar-2
frokostshowet-pa-p5