Decera Clinical Education Infectious Disease Podcast3 Aug 2023

Managing ART Failure: Answering the Questions

In this episode, Daniel R. Kuritzkes, MD, and Cristina Mussini, MD, discuss managing ART failure, including:

The definitions of virologic blips, low-level viremia, and virologic failure on ART
The infrequency of failure with resistance on first-line INSTI-based ART and the instances where this has occurred with BIC- and DTG-based ART in clinical trials and in the real world
The potential reasons for ART failure, including patient/adherence-related factors, HIV-related factors, and regimen-related factors
The impact of adherence on viral suppression with BIC- and DTG-based ART
Drug-drug interactions as a reason for failure of first-line INSTI-based ART
What to do if someone is experiencing virologic failure requiring an ART change
The use of proviral DNA testing in patients with viral suppression or low-level viremia with ART treatment experience
The impact of high HIV-1 RNA on ART effectiveness
The impact of NRTI resistance, including the M184V and K65R mutations, on the effectiveness of BIC- and DTG-based ART
Strategies to encourage and measure patient adherence to ART

Presenters

Daniel R. Kuritzkes, MD
Harriet Ryan Albee Professor of Medicine
Harvard Medical School
Chief, Division of Infectious Diseases
Brigham and Women’s Hospital
Boston, Massachusetts

Cristina Mussini, MD
Professor
Department of Infectious Diseases
University of Modena and
Reggio Emilia
Modena, Italy

Link to full program: https://bit.ly/3HPu4Lk

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