Deborah Wexler on weight gain associations in the GRADE Randomized Controlled Trial, Justin Echouffo-Tcheugui on the success—or lack of success—of the lifestyle modification approach to preventing T2D, and more!

Welcome to episode no. 33 (June 2025) of Diabetes Care "On Air"—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the June 2025 issue of Diabetes Care and beyond.

6:50 Alice is joined by past guest Deborah Wexler, MD, MSC, chief of the Massachusetts General Hospital Diabetes Unit, and Associate Professor of Medicine at Harvard Medical School. They discuss her article, "Weight Gain Was Associated With Worsening Glycemia and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes Independent of Diabetes Medication in the GRADE Randomized Controlled Trial," available for free at doi.org/10.2337/dc24-2825.

18:40 Mike speaks with Justin Echouffo-Tcheugui, MD, PhD, Associate Professor of Medicine in the Division of Endocrinology at Johns Hopkins School of Medicine. They address the core question in his article, "Is the Current Lifestyle Modification Approach to Diabetes Prevention in the U.S. a Success?" available for free at doi.org/10.2337/dci24-0040.

43:20 In the "Diabetes Care Rapid Exchange," Alice and Mike wrap up the episode by reviewing several interesting articles in the May 2025 issue of Diabetes Care. Studies highlighted in this segment include:

• Bapat et al. Capillary Ketone Level and Future Ketoacidosis Risk in Patients With Type 1 Diabetes Using Sodium–Glucose Cotransporter Inhibitors doi.org/10.2337/dc25-0125

• Pitta et al. Empagliflozin in Type 2 Diabetes Undergoing On-Pump CABG: The POST-CABGDM Randomized Clinical Trial doi.org/10.2337/dc24-2807

• Retnakaran et al. 1-hour Oral Glucose Tolerance Test for the Postpartum Reclassification of Women with Hyperglycemia in Pregnancy doi.org/10.2337/dc24-1848

• Ginzberg et al. Islet Autoantibodies and Their Association with β Cell Function and Diabetes Measures in Children with Acute Recurrent and Chronic Pancreatitis doi.org/10.2337/dc24-2672

• Smedegaard et al. Pre-Meal Whey Protein Lowers Postprandial Blood Glucose in Women with Gestational Diabetes Mellitus – A Randomized, Crossover Clinical Trial. doi.org/10.2337/dc24-2831

• Perrier et al. Impact of Islet Transplantation on Diabetic Complications and Mortality in Patients Living with Type 1 Diabetes doi.org/10.2337/dc25-0059

To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.