Tyramine & Histamine: How 2 Hidden Compounds Trigger Migraines and the Shocking Link to Medications

“Just avoid wine and cheese!”

If only it were that simple.

Welcome back to The Migraine Heroes Podcast, where we explore the real reasons behind your attacks and how to stop them. Hosted by Diane Ducarme, who’s helped over 500 women get their lives back, this podcast blends the best of neuroscience with the deep-rooted wisdom of Traditional Chinese Medicine.

In today’s episode, we unpack the controversial world of tyramine and histamine—two compounds that hide in your favorite foods and may be secretly fueling your migraine attacks.

You’ll learn:

• Why fermented, aged, or even slightly spoiled foods can create a “perfect storm” in your brain
• What tyramine and histamine actually do to your nervous system, and why some bodies just can’t process them well
• How medications like NSAIDs, antidepressants, and even common antibiotics can interfere with the body's ability to break down histamine making migraine triggers themselves (!)
• How to build a path back to food freedom—without fear

Whether you’ve been told to cut all histamine-rich foods or you’ve noticed wine, cheese, or avocado leave you foggy and drained, this episode is your science-backed, heart-centered guide to understanding why—and what to do next.

💡 This one’s packed with deep insights, real stories, and a powerful reframe that will change how you approach food forever.

🎧 New episodes drop every Monday and Wednesday.

🔗 Migraine Assessment: Discover your unique Migraine Profile and uncover insights about your migraine triggers and solutions. Take a few minutes for yourself and begin now.✨

📲 Want personalized food support, a migraine tracker, and a holistic plan that evolves with you? Download the Migraine Heroes App today and begin your healing journey.

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Disclaimer: This podcast is for informational purposes only and does not substitute for providing medical advice. Always consult your healthcare professional before making any health-related decisions.

For women, men, and children who suffer from migraine disease, Migraine Heroes is your go-to resource for understanding, managing, and overcoming migraine attacks.

We cover all types of migraines and related headaches, including primary and secondary migraines, chronic migraines, and cluster migraines. We dive deep into the complexities of migraine with aura and migraine without aura, as well as rarer forms like hemiplegic migraine, retinal migraine, and acephalgic migraine (silent migraine). Our discussions also extend to cervicogenic headaches, ice pick headaches, and pressure headaches, which often mimic migraine or contribute to overall migraine burden.