Ep 51 The Path of Most (Antibiotic) Resistance

Ep 51 The Path of Most (Antibiotic) Resistance

No story of antibiotics would be complete without the rise of resistance. As promised in our last episode, this week we dive into what the WHO calls ‘one of the biggest threats to global health, food security, and development today’ - antibiotic resistance. In the decades since their development, misuse and overuse of antibiotics has led to many becoming all but useless, and our world seems on the verge of plunging into a post-antibiotic era. How does resistance work? Where did it come from? Why did it spread so far so rapidly? Is there any hope? In this episode, we answer all these questions and more. First, we explore the many ways bacteria evade the weaponry of antibiotic compounds. Then we trace the global spread of these resistant bugs by examining the major contributors to their misuse and overuse. And finally we assess the current global status of antibiotic resistant infections (spoiler: it’s very bad) and search for any good news (spoiler: there’s a lot!). To chat about one super cool and innovative alternative to antibiotics, we are joined by the amazing Dr. Steffanie Strathdee (Twitter: @chngin_the_wrld), Associate Dean of Global Health Sciences, Harold Simon Professor at the University of California San Diego School of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. Dr. Strathdee provides a firsthand account of helping her husband, Dr. Tom Patterson, fight off a deadly superbug infection by calling on a long-forgotten method of treating bacterial infections: phage therapy.

To read more about phage therapy and Dr. Strathdee’s incredible experiences, check out The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir.

See omnystudio.com/listener for privacy information.

Episoder(281)

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

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Ep 196 Health Myths: Fact or fiction?

Ep 196 Health Myths: Fact or fiction?

Did your grandma ever warn you against going out in the cold with wet hair because “you’ll catch your death”? Or have you ever tossed a few more carrots into your shopping basket in the hope that they...

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Special Episode: Dr. Homer Venters & Outbreak Behind Bars

[Content warning: self-harm, suicide, violence] In this day and age, we are equipped with an abundance of tools and knowledge to fight the spread of disease. Yet what good does that toolkit do if we l...

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Ep 195 Salt Part 2: The Substance

Ep 195 Salt Part 2: The Substance

We ended last week’s episode on a bit of a cliffhanger: is salt actually bad for us and if so, why does there still seem to be a debate? This week’s episode holds all the answers. We’re sifting throug...

2 Des 202553min

Ep 194 Salt Part 1: The Seasoning

Ep 194 Salt Part 1: The Seasoning

Have you ever thrown a pinch of spilled salt over your left shoulder? Or said to someone “well, take his opinion with a grain of salt”? Or looked up the potential salary of a job listing? Salt is so d...

25 Nov 202555min

Special Episode: Gabriel Weston & Alive

Special Episode: Gabriel Weston & Alive

In an anatomy and physiology class, you may learn how the different heart valves work to circulate your blood, how the structure of your kidney helps to maintain electrolyte levels, and how the expans...

18 Nov 202549min

Ep 193 Necrotizing Fasciitis: A strange beast

Ep 193 Necrotizing Fasciitis: A strange beast

If you were asked to describe necrotizing fasciitis in three words, you might choose: rapid, deadly, and rare. The third of those adjectives may provide some comfort, but the first two are the clear i...

11 Nov 20251h 7min

Ep 192 New World Screwworm: Oh-oh here they come

Ep 192 New World Screwworm: Oh-oh here they come

It’s the stuff nightmares are made of. A fly lands on an open wound and lays hundreds of eggs, from which hatch countless ravenous maggots. There they writhe, devouring flesh, insatiable and relentles...

4 Nov 20251h 10min

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