Ep 51 The Path of Most (Antibiotic) Resistance

Ep 51 The Path of Most (Antibiotic) Resistance

No story of antibiotics would be complete without the rise of resistance. As promised in our last episode, this week we dive into what the WHO calls ‘one of the biggest threats to global health, food security, and development today’ - antibiotic resistance. In the decades since their development, misuse and overuse of antibiotics has led to many becoming all but useless, and our world seems on the verge of plunging into a post-antibiotic era. How does resistance work? Where did it come from? Why did it spread so far so rapidly? Is there any hope? In this episode, we answer all these questions and more. First, we explore the many ways bacteria evade the weaponry of antibiotic compounds. Then we trace the global spread of these resistant bugs by examining the major contributors to their misuse and overuse. And finally we assess the current global status of antibiotic resistant infections (spoiler: it’s very bad) and search for any good news (spoiler: there’s a lot!). To chat about one super cool and innovative alternative to antibiotics, we are joined by the amazing Dr. Steffanie Strathdee (Twitter: @chngin_the_wrld), Associate Dean of Global Health Sciences, Harold Simon Professor at the University of California San Diego School of Medicine and Co-Director at the Center for Innovative Phage Applications and Therapeutics. Dr. Strathdee provides a firsthand account of helping her husband, Dr. Tom Patterson, fight off a deadly superbug infection by calling on a long-forgotten method of treating bacterial infections: phage therapy.

To read more about phage therapy and Dr. Strathdee’s incredible experiences, check out The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir.

See omnystudio.com/listener for privacy information.

Episoder(282)

Ep 9 Tuberculosis: A Slow Burn

Ep 9 Tuberculosis: A Slow Burn

Today, we’re taking a page straight out of Dickens and talking about tuberculosis- a disease as rich in history as it is in bloody sputum. We'll travel the path of an individual Mycobacterium tubercul...

2 Jan 201859min

Ep 8 ABRACADABRA - Go Away Malaria!

Ep 8 ABRACADABRA - Go Away Malaria!

It's both a disease of dinosaurs and a plague of people. A gin and tonic might make you forget how much those bites itch, but it won't protect you much from this mosquito-borne monster. That's right p...

19 Des 201759min

Ep 7 Hit Me With Your Best (Polio) Shot

Ep 7 Hit Me With Your Best (Polio) Shot

A scientific rivalry for the ages, a president with a closely kept secret, and a summertime with no pool time. What do all these things have in common? Well step right up and take a listen- today we'r...

12 Des 20171h 1min

Ep 6 Plague Part 2: TGFA

Ep 6 Plague Part 2: TGFA

We're back with another episode all about plague-TGFA: Thank Goodness For Antibiotics! Today we'll focus on the status of plague in the modern world: where it is, where it isn't, and what we can do ab...

5 Des 201740min

Ep 5 Plague Part 1: The GMOAT

Ep 5 Plague Part 1: The GMOAT

That's right y'all... Today we're talking the GMOAT: The GREATEST MORTALITY OF ALL TIME: BLACK DEATH. This episode we'll cover the biology and history of one of the most epic diseases of all time- Yer...

28 Nov 201759min

Ep 4 The Poop Show

Ep 4 The Poop Show

That's right.. this is the poop show! Today we talk cholera- the bacterial disease that makes you liquid-poop your pants (and then some). Travel back in time with us to when London was a sewage-filled...

21 Nov 201749min

Ep 3 Gnarlypox

Ep 3 Gnarlypox

This week we pay tribute to one of the gnarliest diseases of all time, and the only human disease that's ever been eradicated (thus far). That's right, people- we're talking smallpox! It's gonna get g...

14 Nov 201757min

Ep 2 Skin in the Game, Horse in the Race

Ep 2 Skin in the Game, Horse in the Race

This week we tackle leprosy. That biblical (or is it?) infection that, believe it or not, is still with us today. Leprosy has an ancient history that exemplifies some of the worst of human behavior, a...

7 Nov 201754min

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