Ep 59 Thalidomide: Justice Delayed, Justice Denied

Ep 59 Thalidomide: Justice Delayed, Justice Denied

The story of thalidomide is often employed as a cautionary tale - why testing a drug’s safety during pregnancy is crucial or why it’s important to choose the right animal models. Or it’s framed as a success story for drug repurposing or regulation. But those tellings often gloss over the darker lesson of thalidomide: that for some companies, the bottom line is more important than human life. This week, we explore all elements of this infamous drug. We start by examining what we know about how thalidomide causes the severe congenital malformations it’s associated with, and then we dive into the deep, dark history of the drug, complete with a full cast of villains and heroes. Finally, we discuss thalidomide’s controversial comeback as a treatment for myeloma and complications of leprosy. Get out your angry hats for this one, people, because you’ll find yourself asking along with us, “why are humans the way we are?”

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Episoder(292)

Ep 214 Boogers: Digging for treasure

Ep 214 Boogers: Digging for treasure

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30 Jun 1h 2min

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

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23 Jun 57min

Ep 213 Burns Part 2: It’s like sci-fi but real 

Ep 213 Burns Part 2: It’s like sci-fi but real 

At the turn of the 20th century, a severe burn was often a death sentence. Today, that is no longer the case. Over the past eighty years, burn care has undergone a profound transformation thanks to cr...

16 Jun 58min

Ep 212 Burns Part 1: The first million or so years

Ep 212 Burns Part 1: The first million or so years

Burns have been a part of the human experience since our hominin relatives began controlling fire 1.5 million years ago. Until very recently, we’ve been limited in our ability to manage burn wounds wi...

9 Jun 55min

Special Episode: Alexandra Sifferlin & The Elusive Body

Special Episode: Alexandra Sifferlin & The Elusive Body

An accurate diagnosis can give us so much. It can give us a path forward. It can give us answers to long-standing questions. And it can give us much-needed hope. Yet many people around the world wait ...

2 Jun 51min

Ep 211 Motion Sickness: It comes in waves

Ep 211 Motion Sickness: It comes in waves

It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car...

26 Mai 1h 16min

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year...

19 Mai 1h 18min

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So fea...

12 Mai 51min

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