Special Episode: Human African Trypanosomiasis & Drug Development

Special Episode: Human African Trypanosomiasis & Drug Development

Our episode last week ended on a hopeful note, a rare occurrence for this podcast, and it was due in large part to the incredible decline in reported cases of human African trypanosomiasis (HAT) over the past decade. In this bonus episode, we explore one of the major reasons behind this drop in HAT: the new medication fexinidazole, developed through a partnership between the Drugs for Neglected Diseases initiative (DNDi), a non-profit organization dedicated to developing new treatments for neglected diseases and Sanofi, a French healthcare company. We are thrilled to be joined by two researchers from DNDi, Dr. Nathalie Strub-Wourgaft and Dr. Wilfried Mutombo Kalonji, who share their insights into the challenges associated with bringing a medication all the way from its development stage, to testing it in the field, and finally ensuring that access is provided for those who need it most. We also chat about how this treatment works, the impact that COVID-19 has had on screening efforts for sleeping sickness, the lessons learned from fexinidazole’s development, and so much more. Tune in wherever you get your podcasts! And when you’re finished with the ep, check out this beautiful video from DNDi chronicling the story of fexinidazole: A doctor’s dream: A pill for sleeping sickness.

See omnystudio.com/listener for privacy information.

Episoder(282)

Ep 9 Tuberculosis: A Slow Burn

Ep 9 Tuberculosis: A Slow Burn

Today, we’re taking a page straight out of Dickens and talking about tuberculosis- a disease as rich in history as it is in bloody sputum. We'll travel the path of an individual Mycobacterium tubercul...

2 Jan 201859min

Ep 8 ABRACADABRA - Go Away Malaria!

Ep 8 ABRACADABRA - Go Away Malaria!

It's both a disease of dinosaurs and a plague of people. A gin and tonic might make you forget how much those bites itch, but it won't protect you much from this mosquito-borne monster. That's right p...

19 Des 201759min

Ep 7 Hit Me With Your Best (Polio) Shot

Ep 7 Hit Me With Your Best (Polio) Shot

A scientific rivalry for the ages, a president with a closely kept secret, and a summertime with no pool time. What do all these things have in common? Well step right up and take a listen- today we'r...

12 Des 20171h 1min

Ep 6 Plague Part 2: TGFA

Ep 6 Plague Part 2: TGFA

We're back with another episode all about plague-TGFA: Thank Goodness For Antibiotics! Today we'll focus on the status of plague in the modern world: where it is, where it isn't, and what we can do ab...

5 Des 201740min

Ep 5 Plague Part 1: The GMOAT

Ep 5 Plague Part 1: The GMOAT

That's right y'all... Today we're talking the GMOAT: The GREATEST MORTALITY OF ALL TIME: BLACK DEATH. This episode we'll cover the biology and history of one of the most epic diseases of all time- Yer...

28 Nov 201759min

Ep 4 The Poop Show

Ep 4 The Poop Show

That's right.. this is the poop show! Today we talk cholera- the bacterial disease that makes you liquid-poop your pants (and then some). Travel back in time with us to when London was a sewage-filled...

21 Nov 201749min

Ep 3 Gnarlypox

Ep 3 Gnarlypox

This week we pay tribute to one of the gnarliest diseases of all time, and the only human disease that's ever been eradicated (thus far). That's right, people- we're talking smallpox! It's gonna get g...

14 Nov 201757min

Ep 2 Skin in the Game, Horse in the Race

Ep 2 Skin in the Game, Horse in the Race

This week we tackle leprosy. That biblical (or is it?) infection that, believe it or not, is still with us today. Leprosy has an ancient history that exemplifies some of the worst of human behavior, a...

7 Nov 201754min

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