Huberman Lab3 Jul 2025

Essentials: Understanding & Conquering Depression

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Major Depression 00:01:10 Depression Symptoms 00:06:14 Sponsor: BetterHelp 00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin 00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics 00:17:43 Sponsor: AG1 00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise 00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise 00:26:49 Sponsor: Our Place 00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression 00:30:20 Novel Depression Therapies, Ketamine, Psilocybin 00:35:29 Ketogenic Diet & Refractory Depression, GABA 00:37:57 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

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Episoder(454)

Essentials: How Smells Influence Our Hormones, Health & Behavior | Dr. Noam Sobel

In this Huberman Lab Essentials episode, my guest is Dr. Noam Sobel, PhD, a Professor of Neurobiology at the Weizmann Institute of Science and an expert on the human sense of smell. We discuss how the...

29 Okt 34min

Unlocking Persistent Motivation & Extreme Resilience | Ross Edgley

Ross Edgley is a British ultra-endurance athlete and author known for completing extraordinary athletic feats by tapping into diverse sources of motivation and resilience. We discuss the psychological...

26 Okt 2h 43min

Essentials: Developing a Rational Approach to Supplementation for Health & Performance

In this Huberman Lab Essentials episode, I explain how to develop a rational supplementation protocol tailored to your specific needs, nutrition and budget. I discuss foundational supplements and sing...

22 Okt 38min

What Makes Great Leaders & How to Live an Extraordinary Life | Dr. Jared Diamond

Dr. Jared Diamond, PhD, is a Pulitzer Prize-winning author, physiologist, evolutionary biologist and Professor at UCLA. We discuss the surprising and often chance events that shaped human history and ...

19 Okt 1h 53min

Essentials: Neuralink & Technologies to Enhance Human Brains | Dr. Matt MacDougall

In this Huberman Lab Essentials episode, my guest is Dr. Matthew MacDougall, a neurosurgeon at Neuralink. We discuss how brain-machine interfaces could help people with paralysis control computers usi...

15 Okt 34min

How Food Choices Shape Memory, Cognition & Cravings | Dr. Scott Kanoski

Dr. Scott Kanoski, PhD, is a Professor of Human and Evolutionary Biology and Neurobiology at the University of Southern California. We discuss how different foods impact memory and cognitive function ...

12 Okt 2h 2min

Essentials: Manage Stress & Build Resilience | Dr. Elissa Epel

In this Huberman Lab Essentials episode, my guest is Dr. Elissa Epel, PhD, a Professor of Psychiatry and Behavioral Sciences at the University of California, San Francisco (UCSF). We discuss how acute...

8 Okt 34min

Bringing Extinct Species Back to Life | Dr. Beth Shapiro

Dr. Beth Shapiro, PhD, is an evolutionary biologist and Chief Science Officer at Colossal Biosciences. Her work focuses on de-extinction and wildlife conservation efforts. We discuss genetic differenc...

5 Okt 2h 15min