Essentials: Understanding & Conquering Depression
Huberman Lab3 Jul 2025

Essentials: Understanding & Conquering Depression

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Major Depression 00:01:10 Depression Symptoms 00:06:14 Sponsor: BetterHelp 00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin 00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics 00:17:43 Sponsor: AG1 00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise 00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise 00:26:49 Sponsor: Our Place 00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression 00:30:20 Novel Depression Therapies, Ketamine, Psilocybin 00:35:29 Ketogenic Diet & Refractory Depression, GABA 00:37:57 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(393)

How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague

How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read Montague

Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech’s Fralin Biomedical Research Institute and an expert in how dopamine and serotonin sh...

2 Feb 2h 41min

Essentials: Using Play to Rewire & Improve Your Brain

Essentials: Using Play to Rewire & Improve Your Brain

In this Huberman Lab Essentials episode, I discuss why play is a powerful yet often overlooked tool for shaping the brain across the entire lifespan, not just during childhood. I explain how play enga...

29 Jan 35min

Science & Tools of Learning & Memory | Dr. David Eagleman

Science & Tools of Learning & Memory | Dr. David Eagleman

Dr. David Eagleman, PhD, is a neuroscientist, bestselling author and professor at Stanford University. We discuss how to leverage the science of neuroplasticity to learn new skills and information and...

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Essentials: Therapy, Treating Trauma & Other Life Challenges | Dr. Paul Conti

Essentials: Therapy, Treating Trauma & Other Life Challenges | Dr. Paul Conti

In this Huberman Lab Essentials episode, my guest is Dr. Paul Conti, MD, a psychiatrist and expert in treating trauma and psychiatric illness. We explain what trauma is and how it affects the mind a...

22 Jan 38min

Build Muscle & Strength & Forge Your Life Path | Dorian Yates

Build Muscle & Strength & Forge Your Life Path | Dorian Yates

Dorian Yates is a former professional bodybuilder, six-time Mr. Olympia winner and a pioneer of high-intensity, low-volume training for building muscle size and strength. He explains how anyone can va...

19 Jan 2h 47min

Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

In this Huberman Lab Essentials episode, my guest is Dr. Wendy Suzuki, PhD, a professor of neural science and psychology at New York University. We discuss simple, daily habits to improve focus, memo...

15 Jan 41min

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addi...

12 Jan 3h 27min

Essentials: Optimizing Workspace for Productivity, Focus & Creativity

Essentials: Optimizing Workspace for Productivity, Focus & Creativity

In this Huberman Lab Essentials episode, I discuss how to optimize your workspace to maximize productivity, focus and creativity. I explain how key environmental factors such as lighting, the physica...

8 Jan 34min

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