Science Friday8 Aug 2025

Lithium May Have A Role In Causing—And Treating—Alzheimer’s

The mechanisms behind Alzheimer’s disease have eluded scientists for decades. But a new breakthrough points to lithium as a possible explanation—not only does it occur naturally in the brain, but a deficiency causes dementia in mice. This research is one of thousands of projects that have lost funding due to President Trump’s cuts to the National Institutes of Health (NIH).

Host Ira Flatow speaks with Alzheimer’s researcher Bruce Yankner about this new finding, and then to epidemiologist Katelyn Jetelina and immunologist Elisabeth Marnik about the country’s “quiet engine of science,” the NIH.

Guests:
Dr. Bruce Yankner is professor of genetics and neurology at Harvard Medical School in Boston, Massachusetts.
Dr. Katelyn Jetelina, epidemiologist and author of the Your Local Epidemiologist newsletter. She’s based in San Diego.
Dr. Elisabeth Marnik is an immunologist and Director of Science Education & Outreach at the MDI Biological Laboratory in Bar Harbor, Maine.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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