Lead: Oral methadone versus sublingual buprenorphine for the treatment of acute opioid withdrawal: A triple-blind, double-dummy, randomized control trial

Lead: Oral methadone versus sublingual buprenorphine for the treatment of acute opioid withdrawal: A triple-blind, double-dummy, randomized control trial

Oral methadone versus sublingual buprenorphine for the treatment of acute opioid withdrawal: A triple-blind, double-dummy, randomized control trial

Drug and Alcohol Dependence Researchers compared oral methadone to sublingual buprenorphine for the management of acute opioid withdrawal. Patients at an inpatient drug treatment center in India were randomly assigned to receive either methadone or buprenorphine titrated over days 1-3 to control opioid withdrawal symptoms. Over days 4-10 medications were tapered and stopped by day 11. Completion of treatment was similar in both groups (83% methadone, 82% buprenorphine). Both subjective (SOWS) and objective (COWS) withdrawal symptoms decreased during the treatment, however the buprenorphine group had significantly greater withdrawal symptoms than the methadone group (p=0.009) at the end of treatment (day 10). Opioid craving also decreased in both groups with no significant difference between groups. Authors conclude that methadone is a safe and effective alternative to buprenorphine for management of opioid withdrawal.

Read this issue of the ASAM Weekly

Subscribe to the ASAM Weekly

Visit ASAM

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(100)

Lead: Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study

Lead: Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study

Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study Addiction Adolescent past-year cannabis use trends ha...

29 Sep 7min

Lead: Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024

Lead: Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024

Abandonment of prescribed buprenorphine for opioid use disorder, 2020-2024 JAMA Network Open This retrospective cohort study examined characteristics associated with abandonment of newly prescribed bu...

22 Sep 8min

Lead: US drug overdose deaths involving stimulants without opioids continued to rise in 2024

Lead: US drug overdose deaths involving stimulants without opioids continued to rise in 2024

US drug overdose deaths involving stimulants without opioids continued to rise in 2024 Addictive Behaviors Reports Drug overdose deaths (DOD) peaked in 2022 before a decline in rates driven by decreas...

15 Sep 7min

Lead: US drug overdose deaths that occurred in isolation, 2022–2024

Lead: US drug overdose deaths that occurred in isolation, 2022–2024

US drug overdose deaths that occurred in isolation, 2022–2024 NEJM Evidence Data were obtained from SUDORS (State Unintentional Drug Overdose Reporting System) for 2022-2024. Of 191,577 overdose death...

9 Sep 7min

Lead: Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians

Lead: Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians

Nicotine e-cigarettes for cigarette smoking cessation: Recommendations to US-based clinicians Journal of the American Medical Association This Special Communication summarizes the evidence on the use ...

3 Sep 7min

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial The American Journal of Psychiatry Accumulating preclinical and observational evidence suggests that glucagon-like peptide-1 rece...

25 Aug 7min

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic Journal of Substance Use and Addiction Treatment This is an ...

18 Aug 7min

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction Cocaine use disorder (CUD) is an increasingly wi...

11 Aug 7min

Populært innen Politikk og nyheter

giver-og-gjengen-vg
aftenpodden
forklart
aftenpodden-usa
popradet
fotballpodden-2
stopp-verden
dine-penger-pengeradet
rss-espen-lee-usensurert
det-store-bildet
rss-gukild-johaug
nokon-ma-ga
hanna-de-heldige
aftenbla-bla
rss-penger-polser-og-politikk
e24-podden
rss-ness
frokostshowet-pa-p5
bt-dokumentar-2
saken