#106 - Can A Sleeping Pill Help Fight Alzheimer’s?

#106 - Can A Sleeping Pill Help Fight Alzheimer’s?

Matt explores the critical link between sleep and Alzheimer's disease today, explaining how the brain’s "glymphatic system" clears toxic proteins like amyloid and tau during deep sleep. He describes how insufficient sleep impairs this process, creating a vicious cycle where protein accumulation damages sleep-generating brain regions and increases dementia risk. Matt goes on to discuss groundbreaking research on a new class of sleeping pills, Dual Orexin Receptor Antagonists (DORAs), that may ...

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Episoder(185)

#148 - Psychedelics for Mental Health

#148 - Psychedelics for Mental Health

Matt delves into how psychedelics like psilocybin and LSD quiet the "Default Mode Network" to boost neuroplasticity. He describes these molecules as a "crowbar" that allows therapy to break deep-seate...

17 Aug 32min

#147 - Does Sleep Really Clean Your Brain?

#147 - Does Sleep Really Clean Your Brain?

Matt explores the brain's secret plumbing, a waste-clearance network once ignored for over a century. He explains how the glymphatic system flushes metabolic toxins like amyloid-beta during sleep. Thi...

10 Aug 25min

#146 - How Sleep Changes Across the Human Lifespan

#146 - How Sleep Changes Across the Human Lifespan

Matt tracks sleep across the human lifespan, from newborn "active sleep" to the shifts of healthy aging. He explores how biological milestones - like puberty, pregnancy, and menopause - impact rest, r...

3 Aug 20min

#145 - How to get More Deep Sleep

#145 - How to get More Deep Sleep

Matt explains the science of deep sleep, emphasizing that this front-loaded stage is vital for physical and mental repair. To boost it, he recommends "builders" like consistent wake times, daily exerc...

27 Jul 32min

#144 - Face Blindness Explained

#144 - Face Blindness Explained

Matt explores how the brain constructs reality by examining neurological anomalies. He contrasts "super-recognizers" with those living with prosopagnosia, or face blindness. By analyzing the Capgras d...

20 Jul 28min

#143 - The Science of Love, Desire, and Sex

#143 - The Science of Love, Desire, and Sex

Matt examines the neurobiology of love, defining it as a reward system rather than just an emotion. He breaks love into three systems: lust (hormones), attraction (dopamine), and attachment (oxytocin)...

13 Jul 33min

#142 - How Memory Affects Sleep

#142 - How Memory Affects Sleep

Exploring how daily memories shape the biology of sleep, Matt reveals that, beyond consolidating facts, the brain's restorative depth is a response to daytime effort. By showing how learning deepens s...

6 Jul 29min

The Beekeepers Garden -  A Sleep Story Read by Matt Walker

The Beekeepers Garden - A Sleep Story Read by Matt Walker

Matt invites you to embark upon a gentle journey to a peaceful, restful sleep. After settling in and breathing deeply, you will find yourself on a winding lane. Matt guides you past a mossy stone wal...

29 Jun 25min

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