Stop Ignoring hsCRP and the Role of Inflammation in Diminished Ovarian Reserve

If you're facing low AMH, high FSH, DOR, POI, or recurrent pregnancy loss, this episode is for you. We're diving into hsCRP (high-sensitivity C-reactive protein), a key, often overlooked marker of inflammation, and why it matters for fertility.

Learn how chronic inflammation impacts egg quality, implantation, and embryo health, why hsCRP testing is often missed in conventional care, and what functional labs can reveal. We'll also cover homocysteine, ANA, and natural killer cells, plus practical strategies to reduce inflammation and clotting risks for you and your partner.

I'm Sarah Clark, founder of Fab Fertile, and for over a decade, my team has helped 100's of couples improve fertility naturally or through IVF using functional testing and personalized strategies.

In this episode, you'll learn:

• Why hsCRP testing is critical yet often overlooked in fertility care
• How systemic inflammation affects eggs, implantation, embryos, and male fertility
• Other hidden markers, homocysteine, ANA, NK cells, that can influence fertility outcomes
• Functional fertility strategies to lower inflammation, including diet, gut health, stress support, supplements, and hormone optimization
• Real-world case studies showing how addressing inflammation improved fertility, even with low AMH or DOR

🎧 Subscribe to Get Pregnant Naturally for evidence-based guidance on functional fertility, and share this episode with anyone on their fertility journey.

Not sure where to start? Download our most popular guide: Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH it breaks everything down step by step to help you understand your options and take action

For personalized support to improve pregnancy success, book a call here.

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TIMESTAMPS

[00:00] Introduction to hsCRP & Fertility: Why high-sensitivity C-reactive protein matters for egg quality, implantation, recurrent pregnancy loss, and male factor fertility.

[01:00] Functional Fertility Perspective: How low AMH, high FSH, DOR, and POI patients benefit from advanced lab testing beyond conventional IVF bloodwork.

[02:00] Understanding Chronic Inflammation: How subtle, low-grade inflammation impacts hormone signaling, mitochondrial health, uterine blood flow, and implantation success.

[04:00] Testing & Interpreting hsCRP: What functional labs reveal, optimal levels, and why conventional medicine often overlooks this marker.

[06:00] Related Markers & Practical Strategies: Homocysteine, ANA, natural killer cells, and actionable steps, including diet, lifestyle, and supplementation, to reduce inflammation and support fertility.

[00:10:00] NK Cells & Inflammation – Why NK testing is controversial and how functional fertility targets inflammation using hsCRP, ANA, and personalized testing.

[00:12:00] Who Should Test hsCRP – Low AMH, high FSH, DOR, POI, recurrent loss, IVF failures, male factor, clotting issues, or chronic inflammation.

[00:13:00] Anti-Inflammatory Diet – Whole foods, omega-3s, elimination diet, gut health, and food reintroduction to support egg quality.

[00:16:00] Stress & Immune Support – Meditation, restorative yoga, sleep, supplements (Vitamin D, Omega-3, Curcumin, CoQ10), and blood sugar balance.

[00:19:00] Client Success Story – Addressing gut, hormones, inflammation, and stress led to natural conception; highlights functional fertility testing and strategies.

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RESOURCES

📩 Get your free 10-day elimination diet plan! Email hello@fabfertile.ca with the subject line 10 DAY to receive your guide and take the first step toward reconnecting with your fertility.

Why Addressing Homocysteine Levels Can Boost Egg and Sperm Health: https://fabfertile.com/blogs/podcasts/why-addressing-homocysteine-levels-can-boost-egg-and-sperm-health?_pos=1&_sid=719b8a8db&_ss=r

The Clotting Connection: Hidden Causes of Implantation Failure and Miscarriage: https://fabfertile.com/blogs/podcasts/the-clotting-connection-hidden-causes-of-implantation-failure-and-miscarriage?_pos=1&_sid=5b40c230d&_ss=r

Causes of Miscarriage Before 12 Weeks: What Most Doctors Miss: https://fabfertile.com/blogs/podcasts/causes-of-miscarriage-before-12-weeks-what-most-doctors-miss?_pos=12&_sid=27a161a55&_ss=r

Improving Egg Quality and Fertility: The Gut Fertility Connection for Low AMH, High FSH, and Poor Egg Quality: https://fabfertile.com/blogs/podcasts/improving-egg-quality-and-fertility-the-gut-fertility-connection-for-low-amh-high-fsh-and-poor-egg-quality?_pos=8&_sid=11eaad983&_ss=r

Could My Fertility Stress and Control Issues Be Lowering My AMH?: https://fabfertile.com/blogs/podcasts/could-my-fertility-stress-and-control-issues-be-lowering-my-amh?_pos=9&_sid=f009bd3cc&_ss=r

Our favorite fertility tracker Inito (use code FABFERTILE15 to save 15)

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💛 Join my free Facebook group: Get Pregnant Naturally With Low AMH and/or High FSH: https://www.facebook.com/groups/451444518397946

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Please note we only promote products that Sarah Clark or her Fab Fertile team has tried and believes are beneficial for someone who is TTC. We may receive a small commission