MS-Perspektive - The Multiple Sclerosis Podcast3 Sep 2025

#129: Hope for Myelin Repair: How Stem Cells Could Change the Future of Progressive MS with Dr. Luca Peruzzotti Jametti

Neural stem cells may calm brain inflammation and enable myelin repair in progressive MS. Safety looks promising; phase-2 planning is underway.

You can read the interview extract on my blog: https://ms-perspektive.com/129-luca-peruzzotti-jametti

Progressive MS needs therapies that work inside the brain. In this episode, Dr. Luca Peruzzotti Jametti explains why remyelination is so hard in humans, how neural stem cells (NSCs) can calm chronic inflammation through paracrine signals, and when true myelin repair may be feasible. We discuss Phase-1 safety data, the road to Phase-2, who might benefit first (likely progressive MS), and how metabolic approaches to mitochondria/bioenergetics could stack with cell therapies. Dr. Jametti also shares a realistic timeline (5–10 years for larger trials) and a hopeful outlook on disability reversal within 10–15 years. Resources and lab/social links below.

We cover:

Relapses vs. PIRA and microglia
Why human remyelination often stalls
NSCs: paracrine effects vs. cell replacement
Safety and delivery routes (intraventricular/intrathecal)
Who/when to treat; aHSCT sequencing
Mitochondrial metabolism strategies and the bigger pipeline

How and where can interested people follow your research activities?

Follow the team via the Progressive MS (Cambridge) Facebook page, BlueSky, and Cambridge lab pages. You can also follow our work through the Progressive MS Alliance and the RESTORE consortium.

Dr. Luca Peruzzotti Jametti on PubMed

References & Related Episodes/Topics

Phase-1 NSC transplantation in progressive MS (Cell Stem Cell, 2023) – discussed in interview.
Progressive MS Alliance – supporting phase-2 planning.
Upcoming therapies mentioned: BTK inhibitors.

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See you soon and try to make the best out of your life,
Nele

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