#521: Red Teaming LLMs and GenAI with PyRIT

#521: Red Teaming LLMs and GenAI with PyRIT

English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If you connect a model to tools or let it read documents from the wild, you have created a brand new attack surface. In this episode, we will make that concrete. We will talk about the attacks teams are seeing in 2025, the defenses that actually work, and how to test those defenses the same way we test code. Our guides are Tori Westerhoff and Roman Lutz from Microsoft. They help lead AI red teaming and build PyRIT, a Python framework the Microsoft AI Red Team uses to pressure test real products. By the end of this hour you will know where the biggest risks live, what you can ship this quarter to reduce them, and how PyRIT can turn security from a one time audit into an everyday engineering practice.

Episoder(521)

#514: Python Language Summit 2025

#514: Python Language Summit 2025

Every year the core developers of Python convene in person to focus on high priority topics for CPython and beyond. This year they met at PyCon US 2025. Those meetings are closed door to keep focused and productive. But we're lucky that Seth Michael Larson was in attendance and wrote up each topic presented and the reactions and feedback to each. We'll be exploring this year's Language Summit with Seth. It's quite insightful to where Python is going and the pressing matters.

18 Jul 1h 13min

#513: Stories from Python History

#513: Stories from Python History

Why do people listen to this podcast? Sure, they're looking for technical explorations of new libraries and ideas. But often it's to hear the story behind them. If that speaks to you, then I have the perfect episode lined up. I have Barry Warsaw, Paul Everitt, Carol Willing, and Brett Cannon all back on the show to share stories from the history of Python. You'll hear about how import this came to be and how the first PyCon had around 30 attendees (two of whom are guests on this episode!). Sit back and enjoy the humorous stories from Python's past.

14 Jul 1h 8min

#512: Building a JIT Compiler for CPython

#512: Building a JIT Compiler for CPython

Do you like to dive into the details and intricacies of how Python executes and how we can optimize it? Well, do I have an episode for you. We welcome back Brandt Bucher to give us an update on the upcoming JIT compiler for Python and why it differs from JITs for languages such as C# and Java.

2 Jul 1h 8min

#511: From Notebooks to Production Data Science Systems

#511: From Notebooks to Production Data Science Systems

If you're doing data science and have mostly spent your time doing exploratory or just local development, this could be the episode for you. We are joined by Catherine Nelson to discuss techniques and tools to move your data science game from local notebooks to full-on production workflows.

25 Jun 54min

#510: 10 Polars Tools and Techniques To Level Up Your Data Science

#510: 10 Polars Tools and Techniques To Level Up Your Data Science

Are you using Polars for your data science work? Maybe you've been sticking with the tried-and-true Pandas? There are many benefits to Polars directly of course. But you might not be aware of all the excellent tools and libraries that make Polars even better. Examples include Patito which combines Pydantic and Polars for data validation and polars_encryption which adds AES encryption to selected columns. We have Christopher Trudeau back on Talk Python To Me to tell us about his list of excellent libraries to power up your Polars game and we also talk a bit about his new Polars course.

18 Jun 1h 2min

#509: GPU Programming in Pure Python

#509: GPU Programming in Pure Python

If you're looking to leverage the insane power of modern GPUs for data science and ML, you might think you'll need to use some low-level programming language such as C++. But the folks over at NVIDIA have been hard at work building Python SDKs which provide nearly native level of performance when doing Pythonic GPU programming. Bryce Adelstein Lelbach is here to tell us about programming your GPU in pure Python.

11 Jun 57min

#508: Program Your Own Computer with Python

#508: Program Your Own Computer with Python

If you've heard the phrase "Automate the boring things" for Python, this episode starts with that idea and takes it to another level. We have Glyph back on the podcast to talk about "Programming YOUR computer with Python." We dive into a bunch of tools and frameworks and especially spend some time on integrating with existing platform APIs (e.g. macOS's BrowserKit and Window's COM APIs) to build desktop apps in Python that make you happier and more productive. Let's dive in!

6 Jun 1h 11min

#507: Agentic AI Workflows with LangGraph

#507: Agentic AI Workflows with LangGraph

If you want to leverage the power of LLMs in your Python apps, you would be wise to consider an agentic framework. Agentic empowers the LLMs to use tools and take further action based on what it has learned at that point. And frameworks provide all the necessary building blocks to weave these into your apps with features like long-term memory and durable resumability. I'm excited to have Sydney Runkle back on the podcast to dive into building Python apps with LangChain and LangGraph.

2 Jun 1h 3min

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