What's Up Docs?30 Sep 2025

Can psychedelics improve your mental health?

Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing.

This week, Chris and Xand meet Dr James Rucker, a consultant psychiatrist at King's College London who is leading the European arm of a global trial of a psychedelic called psilocybin in a study designed to treat people with severe depression for whom other pharmacological treatments have failed.

The use of psychedelics in both traditional medicinal and spiritual ceremonies dates back thousands of years and examples include peyote and ayahuasca from Central and South America, Iboga root from Central Africa and LSD, which is synthesised from a fungus found throughout Europe. As the number of clinical trials involving psychedelics increases, scientists are cautiously optimistic that they may be able to help with a range of conditions from eating disorders and anxiety to depression and addiction.

If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

Presenters: Drs Chris and Xand van Tulleken Guest: Dr James Rucker Producer: Jo Rowntree Executive Producer: Rami Tzabar Editor: Kirsten Lass Assistant Producer: Maia Miller-Lewis Assistant Producer and Researcher: Emily Bird Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

A Loftus Media production for BBC Radio 4

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