#177 — Psychedelic Science

#177 — Psychedelic Science

Sam Harris speaks with Roland Griffiths about the current state of research on psychedelics. They discuss the historical prohibition against their use; the clinical and scientific promise of psilocybin, mescaline, LSD, DMT, MDMA, and other compounds; the risks associated with these drugs; the role of "set and setting"; the differences between psychedelics and drugs of abuse; MDMA and neurotoxicity; experiences of unity, sacredness, love, and truth; the long-term consequences of psychedelic experiences; synthetic vs natural drugs; the prospects of devising new psychedelics; microdosing; research on psilocybin and long-term meditators; the experience of encountering other apparent beings; psilocybin treatment of addiction; and other topics. In his Afterword, Sam discusses his experience on a large dose of psilocybin—his first psychedelic experience in 25 years.

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Episoder(505)

#490 — Lies, Bulls**t, and the Rule of Law

#490 — Lies, Bulls**t, and the Rule of Law

Sam Harris speaks with Preet Bharara about the collapse of good faith debate in American politics. They discuss the fragmentation of media, the treatment of Anthony Fauci, the rush to prosecute politi...

25 Aug 24min

#489 — More From Sam: A Fabulist at Cambridge, the Strait of Hormuz, AOC in 2028, and More

#489 — More From Sam: A Fabulist at Cambridge, the Strait of Hormuz, AOC in 2028, and More

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the death of Cambridge professor Jason Arday and the institutions that promoted him, America's...

21 Aug 23min

#150 — The Map of Misunderstanding (From the Archive)

#150 — The Map of Misunderstanding (From the Archive)

From the archive: In this 2019 episode, Sam Harris speaks with Daniel Kahneman at the Beacon Theatre in NYC. They discuss the replication crisis in science, System 1 and System 2, where intuitions rel...

11 Aug 47min

#488 — Ego, Ecstasy, and Equanimity

#488 — Ego, Ecstasy, and Equanimity

Sam Harris speaks with Neal Brennan about the experiences that shaped his life and work. They discuss Sam's mother's television career, growing up with an absent father, his struggles with perfectioni...

4 Aug 12min

#487 — Is AI Already Conscious?

#487 — Is AI Already Conscious?

Sam Harris speaks with Cameron Berg about whether AI systems are or could become conscious. They discuss self-reports in LLMs, what models say when deception is switched off, the "bliss attractor" sta...

31 Jul 1h 25min

#486 — Luck All the Way Down

#486 — Luck All the Way Down

Sam Harris speaks with Kathryn Paige Harden about behavioral genetics, moral luck, and the problem of blame. They discuss Harden's book Original Sin, the controversy over Charles Murray and Ezra Klein...

22 Jul 21min

#485 — The New Science of Cancer

#485 — The New Science of Cancer

Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies, whether cancer is one disease or many, why prevention is so ha...

14 Jul 1h 21min

#484 — Artificial Intimacy

#484 — Artificial Intimacy

Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the imp...

8 Jul 27min

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