TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful

TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• VITT-like disorder after adenovirus infection (NEJM)
• The clot thickens (TWiV 842)
• Lessons from VITT (Nat Rev Immunol)
• Pan-sarbecovirus neutralizing mAb (Sci Adv)
• Letters read on TWiV 1037
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope
Brianne – Question Mark in Space?
Kathy – Quammen interview with Walter Isaacson
Rich – Chrome Music Lab
Vincent – Matters Microbial

Listener Picks

Tom – The (second) deadliest virus
Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III)
Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv