The Resus Room15 Okt 2019

Can TXA save lives in head injuries, CRASH-3; Roadside to Resus

So an incredibly important paper, CRASH-3 has just been published in the Lancet, which looks at the treatment of head injuries with Tranexamic Acid (TXA).

TXA has been shown to save lives in trauma patients at the risk of major haemorrhage, with the notable exclusion of those with head injuries, CRASH-2. TXA has been shown to save lives in those with post parts haemorrhage, WOMAN trial. Time to treatment with TXA has been shown to be hugely influential in it's ability to decrease blood loss and save lives. So has TXA now been shown to save lives in head injuries?

In this episode we run through the paper and are lucky enough to have an interview with the lead author, Professor Ian Roberts.

Have a listen, read the paper and as always we'd love to hear any thoughts or comments you have on the website and via twitter, and take a look at the references below to draw your own conclusions.

Enjoy!

Simon, Rob & James

References

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.Roberts I. Health Technol Assess. 2013

CRASH-2;The Bottom Line

Effectof earlytranexamic acidadministrationon mortality, hysterectomy, and othermorbiditiesin womenwith post-partum haemorrhage(WOMAN): an international, randomised, double-blind, placebo-controlledtrial. WOMANTrialCollaborators.Lancet 2017

WOMAN Trial;The Bottom Line

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.Gayet-Ageron A. Lancet. 2017

Tranexamic Acid - The Mechanism of Action;Video

Tranexamic Acid, Time to Treatment;The Resus Room

Does earlier TXA save lives?St Emlyns

TXA podcast; PHEMCAST

About CRASH-3; LSHTM

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(286)

August 2026; papers of the month

This month we've got another really varied mix of papers that all have the potential to influence everyday emergency and prehospital practice. We start by asking a question that's becoming increasingl...

2 Aug 35min

Laryngectomy and Tracheostomy Emergencies; Roadside to Resus

Tracheostomy and laryngectomy emergencies are classic high-acuity, low-frequency situations. They do not happen every day, but when they do, airway problems can develop quickly, and the wrong interven...

16 Jul 50min

July 2026; papers of the month

Welcome back to July's Papers of the Month. This month we've got three papers that tackle some of the biggest questions we face in emergency and critical care medicine. They're all very different stud...

1 Jul 31min

Excellence in Facemask Ventilation; Roadside to Resus

Face mask ventilation is one of those skills that can easily be overlooked. It's often seen as the simple bit of airway management — something that sits below the glamour of videolaryngoscopy, fibre-o...

16 Jun 59min

June 2026; papers of the month

This month's episode takes us deep into trauma care, but not just the medicine we deliver but also the systems, circumstances and social factors that shape who survives and who doesn't. We start by lo...

1 Jun 32min

Reframing Anaphylaxis; Roadside to Resus

Anaphylaxis is one of those conditions we think we have got pretty well sorted. Recognise it early, give adrenaline, support the airway and circulation, and crack on. And in fairness, for the vast maj...

14 Mai 44min

May 2026; papers of the month

This month's Papers of the Month is a real mix of papers that challenge some of the things we think we know, whilst also highlighting just how important systems and processes are in improving patient ...

1 Mai 33min

Excellence in Defibrillation; Roadside to Resus

Timely and effective defibrillation is fundamental to excellent outcomes in cardiac arrest care. But there is a growing body of evidence suggesting that how we deliver those shocks may matter just as ...

8 Apr 47min