Part 96 - Dr. Paul Saladino on PUFAs, Insulin Resistance, Visceral Fat, and Longevity

Hey hey everybody, hope you're ready for another information dense episode. We have Dr. Paul Saladino back on to dive deep on how insulin resistance develops. This is a perfect follow up to Dr. Ben Bikman on the last episode explaining to us how insulin resistance and other problems with insulin are the root cause to almost all chronic disease. It's also a great follow up to the many guests who have been talking about the dangers of industrial seed oils, euphemistically known as vegetable oils, and high levels of polyunsaturated fatty acids also known as PUFAs in our diet.

I was thinking about this after we finished recording and thought I could have made a few more points and perhaps made this analogy. Maybe the disease process is like a hammer and a nail. You need both to create something. Either on their own might not be enough. Refined sugars and refined grains would be the hammer and the high PUFAs are the nail. Either one doesn't cause insulin resistance on its own. There's examples of populations eating high carb but not getting insulin resistance (although most of this is whole food carbs). But these people aren't getting a ton of seed oils (possibly zero) in their diet. And there also are examples of people potentially consuming a high amount of PUFAs (like one of the Blue Zones here in the Los Angeles area, Loma Linda) where they avoid a lot of animal products and presumably use vegetable oils as the guidelines dictate.

These people have many other great lifestyle factors and remain thin over their life and they tend to have a disproportionate amount of centenarians. They do all the healthy behaviors to remain thin like avoiding sugars, processed foods, alcohol, and staying active. So basically these people never overstuff their fat cells and start the process of insulin resistance that maybe the high PUFAs would have then been there to cause the real damage. If you have all the other bases covered maybe you can get away with more PUFAs in your diet. There's some epidemiology that suggests this as well.

I'm not saying this is ideal at all, and likely it's best to reduce seed oils as much as possible. I also am just theororizing here. It's interesting to think about the many factors that play into this complex process nobody has definitively solved because there always seems to be some counter-evidence to every theory and I want to take it all into consideration and not just blame things on a single villain.

Please listen to this episode and let me know what you think. I'm on all major social media platforms if you search "food lies" and try to message everyone I can back.

Before we jump in I'll do my new thing of mentioning my conflicts of interest. I believe I have none because I take no outside funding or advertising dollars for any products. I do have a company called Nose to Tail that you can find at http://NoseToTail.org where we deliver grass fed and grass finished beef and buffalo and high omega 3 and low omega 6 chicken and pork to your door. This is all raised here in America and not brought in from Australia or New Zealand like some other companies.

I also am partnered with doctor Gary here in Los Angeles where we have a program to reverse and treat chronic disease and obesity. We see patients in clinic at Evolve Healthcare and online as well. You can find out more at http://Sapien.org or http://sapienprogram.com

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Today in this bonus episode I talked to Paul about the coca-cola funded lobbying and real conflicts of interest, the calorie in - calorie out equation, and what other things factor into the equation besides food. Joining the Tribe is really a win-win for all parties. Members get a whole bunch of perks and features and it also makes all the content creation possible on our end. Go to http://Sapien.org and find out about all these things I mentioned.

Without further ado, here's Paul.

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SHOW NOTES

• [10:40] How and why PUFAs are the true enemy of the chronic disease crisis.
• [16:10] Carbohydrates do not cause insulin resistance.
• [21:40] Difference between a processed and unprocessed carbohydrates.
• [26:10] Why having too much linoleic acid is bad for your health.
• [34:40] Studies that show the mechanisms behind why linoleic acid is responsible for metabolic dysfunction.
• https://pubmed.ncbi.nlm.nih.gov/9488997/
• https://www.sciencedirect.com/science/article/abs/pii/S0952327812001469
• https://www.ncbi.nlm.nih.gov/pubmed/2643423
• https://www.ncbi.nlm.nih.gov/pubmed/23386268
• [46:10] How our body uses our fat cells for communication and signaling.
• [51:10] The negatives of linoleic acid and benefits of stearic acid.
• https://www.nature.com/articles/s41467-018-05614-6?fbclid=IwAR17XRTHYulrCpvlQ_0eo-m71Pu3I3BkPwHHSRvOiHixmf9tdH6HmvjxPDk
• https://pubmed.ncbi.nlm.nih.gov/25222131/
• [58:10] When you give your cells PUFAs your cells remain insulin sensitive, when you give them saturated they become insulin resistant.
• https://www.researchgate.net/profile/Robert_Hegele/publication/10954408_Elevated_serum_C-reactive_protein_and_free_fatty_acids_among_nondiabetic_carriers_of_missense_mutations_in_the_gene_encoding_lamin_AC_LMNA_with_partial_lipodystrophy/links/54de5a940cf2510fcee384c2/Elevated-serum-C-reactive-protein-and-free-fatty-acids-among-nondiabetic-carriers-of-missense-mutations-in-the-gene-encoding-lamin-A-C-LMNA-with-partial-lipodystrophy.pdf
• [1:07:40] The importance of nose to tail foods in an animal based diet.
• [1:12:45] The plant toxicity spectrum.
• [1:15:40] Paul's thoughts on longevity, mTor, and intermittent fasting.

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