PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

This is a joint episode recorded with Dr. Chloe Gomez of the My Favorite Learner podcast. This episode explores the foundational concepts of pharmacogenetics and its impact on drug responses during anesthesia, highlighting how genetic, genomic, and epigenetic variations shape individual reactions to commonly used medications in perioperative care. Designed for nurse anesthesia residents, the show walks through the scenarios of variable drug response, the roles of metabolizing enzymes, transport molecules, and molecular targets, as well as the influence of environmental factors and polymorphisms such as single-nucleotide variants and ethnic differences in metabolism. Key topics include disease-specific considerations like G6PD deficiency, acute intermittent porphyria, long QT syndrome, Brugada syndrome, atypical pseudocholinesterase, and malignant hyperthermia, with a focus on clinical implications for personalized medicine, precision dosing, and ethical issues surrounding genetic testing, privacy, and patient equity. Practical advice covers vigilant monitoring, individualized dosing, preoperative assessment for genetic risk, and strategies for documenting and communicating findings for safer anesthesia practice.

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Episoder(83)

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TRAUMA ANESTHESIA SERIES (PART 5): ANESTHETIC MANAGEMENT | EP49

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In this episode of the Trauma and Burn Anesthesia Series, we take a deep dive into one of the most critical moments in trauma care: the induction and maintenance of anesthesia in hemodynamically unsta...

15 Sep 202526min

TRAUMA ANESTHESIA SERIES (PART 4): AIRWAY MANAGEMENT & IV ACCESS | EP48

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In part 4 of the Trauma and Burn Anesthesia series, we turn to the critical steps of securing the airway, establishing reliable vascular access, and safely transitioning the patient from the trauma ba...

11 Sep 202541min

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In part 3 of the Trauma and Burn Anesthesia series, we focus on blood product administration and fluid resuscitation, exploring how transfusions are tailored to support oxygen delivery, coagulation, a...

8 Sep 202523min

TRAUMA ANESTHESIA SERIES (PART 2): UNDERSTANDING HEMORRHAGE & COAGULOPATHIES | EP46

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In part 2 of the Trauma and Burn Anesthesia series, we discuss hemorrhage management in trauma, covering the causes and treatment of trauma-induced coagulopathies and the significance of essential lab...

2 Sep 202533min

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In this first installment of the Trauma and Burn Anesthesia series, we dive into the critical foundations of caring for severely injured patients in the perioperative setting. Designed for nurse anest...

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18 Aug 202516min

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