Atomic Anesthesia13 Okt 2025

PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

This is a joint episode recorded with Dr. Chloe Gomez of the My Favorite Learner podcast. This episode explores the foundational concepts of pharmacogenetics and its impact on drug responses during anesthesia, highlighting how genetic, genomic, and epigenetic variations shape individual reactions to commonly used medications in perioperative care. Designed for nurse anesthesia residents, the show walks through the scenarios of variable drug response, the roles of metabolizing enzymes, transport molecules, and molecular targets, as well as the influence of environmental factors and polymorphisms such as single-nucleotide variants and ethnic differences in metabolism. Key topics include disease-specific considerations like G6PD deficiency, acute intermittent porphyria, long QT syndrome, Brugada syndrome, atypical pseudocholinesterase, and malignant hyperthermia, with a focus on clinical implications for personalized medicine, precision dosing, and ethical issues surrounding genetic testing, privacy, and patient equity. Practical advice covers vigilant monitoring, individualized dosing, preoperative assessment for genetic risk, and strategies for documenting and communicating findings for safer anesthesia practice.

💜 LIVE WEBINAR: Save your seat on our monthly, free webinars. Replays are sent to your inbox and you get access to all of our previous webinars.

[WEBINAR SIGN UP]

💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets.

[SEE/NCE STUDY PLAN]

[RN ICU DRUG CHART]

💜 CONNECT: 📥 Email questions, comments or topic suggestions to Dr. Temmermand at hello@atomicanesthesia.com, follow us on social media, and sign up for our launch newsletter ⬇️

[NEWSLETTER SIGN-UP]

[INSTAGRAM] [TIKTOK] [YOUTUBE]

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(111)

THE DIFFICULT AIRWAY ALGORITHM, STEP-BY-STEP │ EP111

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse ane...

4 Sep 19min

10 HIGH-YIELD SEE/NCE BOARD QUESTIONS EXPLAINED │ EP110

1 Sep 26min

PREECLAMPSIA AND THE OB PATIENT: PATHOPHYSIOLOGY THAT SAVES LIVES │ EP109

21 Aug 10min

CRNA WORKFORCE CHANGES: DO THESE THINGS TO LAND YOUR PERFECT JOB │ EP108

14 Aug 18min

REGIONAL ANESTHESIA 101: BLOCKS EVERY CRNA SHOULD KNOW │ EP107

Regional anesthesia is one of the highest-yield, most heavily tested areas on the boards, but most review content buries the clinically useful details under anatomy that never gets asked. This episode...

13 Aug 14min

THE 5 OPIOIDS YOU ACTUALLY USE IN THE OR │ EP106

Understanding opioid selection in the OR is all about recognizing pharmacokinetics and how they align with surgical needs and patient factors, rather than focusing solely on receptor effects. This epi...

7 Aug 13min

COMPLEX I, SEVOFLURANE, AND THE VENEZUELAN MITOCHONDRIAL VARIANT │ EP105

A recently identified genetic mutation, passed down on the maternal line, can cause otherwise healthy patients to develop severe and often permanent neurological injury after routine sevoflurane expos...

31 Jul 13min

PROPOFOL: THE DRUG YOU THINK YOU KNOW │ EP104

Propofol, a cornerstone in anesthesia practice, functions as a positive allosteric modulator at the GABA-A receptor. This episode explores its receptor pharmacology, the mechanisms behind its dose-dep...

28 Jul 12min