PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

This is a joint episode recorded with Dr. Chloe Gomez of the My Favorite Learner podcast. This episode explores the foundational concepts of pharmacogenetics and its impact on drug responses during anesthesia, highlighting how genetic, genomic, and epigenetic variations shape individual reactions to commonly used medications in perioperative care. Designed for nurse anesthesia residents, the show walks through the scenarios of variable drug response, the roles of metabolizing enzymes, transport molecules, and molecular targets, as well as the influence of environmental factors and polymorphisms such as single-nucleotide variants and ethnic differences in metabolism. Key topics include disease-specific considerations like G6PD deficiency, acute intermittent porphyria, long QT syndrome, Brugada syndrome, atypical pseudocholinesterase, and malignant hyperthermia, with a focus on clinical implications for personalized medicine, precision dosing, and ethical issues surrounding genetic testing, privacy, and patient equity. Practical advice covers vigilant monitoring, individualized dosing, preoperative assessment for genetic risk, and strategies for documenting and communicating findings for safer anesthesia practice.

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Episoder(87)

DOCTORAL DEGREE FOR CRNAS (PhD, DNP, DNAP) - WHAT'S THE DIFFERENCE? │ EP23

DOCTORAL DEGREE FOR CRNAS (PhD, DNP, DNAP) - WHAT'S THE DIFFERENCE? │ EP23

This podcast episode covers doctoral degrees available to CRNAs, including DNP, DNAP, and different types of PhDs. This episode discusses their distinctions, application requirements, completion timel...

26 Jan 202556min

INTRO TO LOCAL ANESTHETICS - MECHANISM, STRUCTURE, USES & SIDE EFFECTS  │ EP22

INTRO TO LOCAL ANESTHETICS - MECHANISM, STRUCTURE, USES & SIDE EFFECTS │ EP22

In this episode, Professor Rhea Temmermand gives nurse anesthesia residents and aspiring CRNA students a introduction to the pharmacology of LOCAL ANESTHESIA. Discover the fundamental structure, class...

19 Jan 202529min

DEVELOPING PERSONALITY TRAITS +  EFFECTIVE COMMUNICATION SKILLS FOR SUCCESS IN THE OR │ EP21

DEVELOPING PERSONALITY TRAITS + EFFECTIVE COMMUNICATION SKILLS FOR SUCCESS IN THE OR │ EP21

In this episode, Professor Temmermand discusses the importance of effective communication and how it can make our break people's perception of you in the clinical setting. She also discusses character...

12 Jan 202532min

PROTAMINE: REACTIONS, SYMPTOMS + TREATMENT │ EP20

PROTAMINE: REACTIONS, SYMPTOMS + TREATMENT │ EP20

In this episode of the Atomic Podcast, practicing CRNA Alex Gorman dives into the complexities of protamine, a critical medication used to reverse heparin's anticoagulant effects in cardiac and vascul...

5 Jan 202510min

SUBSTANCE USE DISORDER (PART 2) - PHARMACOLOGY AND MANAGEMENT  │ EP19

SUBSTANCE USE DISORDER (PART 2) - PHARMACOLOGY AND MANAGEMENT │ EP19

In this episode, Atomic Anesthesia Co-Founder Rhea Temmermand dives into the critical and nuanced topic of managing pain in patients with substance use disorder (SUD). From understanding the pharmacol...

29 Des 202429min

TWO HEART MODEL - A UNIQUE APPROACH TO UNDERSTANDING CARDIAC PHYSIOLOGY  │ EP18

TWO HEART MODEL - A UNIQUE APPROACH TO UNDERSTANDING CARDIAC PHYSIOLOGY │ EP18

In this episode of the Atomic Podcast, Alex Gorman, a practicing CRNA and cardiac anesthesia expert, introduces the "Two Heart Model," a unique approach to understanding cardiac physiology and pathoph...

22 Des 202410min

DURAL PUNCTURE EPIDURAL - SHOULD YOU DO IT? │ EP17

DURAL PUNCTURE EPIDURAL - SHOULD YOU DO IT? │ EP17

In this episode of the Atomic Podcast, practicing CRNA Alex Gorman discusses the dural puncture epidural (DPE), particularly in the obstetrical setting. By incorporating a spinal needle to confirm mid...

15 Des 202412min

EXPAREL: INTRO + QUICK TIPS WITH ALEX GORMAN, CRNA │ EP16

EXPAREL: INTRO + QUICK TIPS WITH ALEX GORMAN, CRNA │ EP16

In this special short-form episode, practicing CRNA and Atomic Anesthesia content expert Alex Gorman dives into the use of liposomal Bupivacaine (Exparel) in regional anesthesia, highlighting its uniq...

8 Des 20249min

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