Biohacking News Weekly Update : 1351

Biohacking News Weekly Update : 1351

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.


This episode covers:


Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm


The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html


FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter


Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/


Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/


This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.


With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.


New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.


Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human Upgrade


Thank you to our sponsors!

TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

HeartMath | Go to https://www.heartmath.com/dave to save 15% off.


Timestamps:

0:00 — Introduction

0:18 — Story 1: Vitamin D & Telomeres

1:02 — Story 2: Longevity Gene Therapy

1:49 — Story 3: FDA Supplement Reform

2:38 — Story 4: Gut Bacteria & Autophagy

3:46 — Story 5: Medical Avatars

4:53 — Weekly Protocol

5:42 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1411)

Podcast #36:Hacking your Biome with uBiome's Jessica Richman

Podcast #36:Hacking your Biome with uBiome's Jessica Richman

Jessica Richman started and sold her first company after high school. Returning to formal education, she attended Stanford University, where she earned degrees in Economics and Science, Technology & Society (emphasis in computer science). Along the way, she worked for Google, McKinsey, Lehman Brothers, the Grameen Bank, and top-tier Silicon Valley venture firms. Currently a doctoral student at Oxford University, her academic interests include social networks, innovation, collective intelligence, and entrepreneurship. uBiome is the world’s first effort to map the human microbiome with citizen science. While the sequencing of the human genome has provided invaluable knowledge, it is very difficult to change our own genetic makeup. The microbiome, in contrast, is much more easily changed through simple means such as healthful probiotic cultures and other lifestyle interventions. The microbiome thus may provide some of the most important medical breakthroughs of our era. uBiome will ultimately empower participants to manage their microbiomes to improve their health as well as make important scientific discoveries for humanity. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Jan 201331min

Podcast #35: Bulletproof Your Nervous System with Jay Schroeder

Podcast #35: Bulletproof Your Nervous System with Jay Schroeder

World-class strength and neurological conditioning authority, and creator of new technology that stimulates rapid nervous system and cellular improvements He has studied the greatest training systems of the world, not to find the successes but to establish the point at which they failed. He then put together his system of training to overcome these points of failure. He has traveled to Eastern bloc countries and developed working relationships with some of the most knowledgeable in the field. He has designed unique protocols for use with his device as well as the typical equipment in the gym setting, as they relate to rehab strength, injury prevention and elite athletic mastery. Elite level pro athletes pay more than $50,000 to train with Jay. He has designed unique protocols for use with the ARP as well as the typical equipment in the gym setting, as they relate to rehab strength, injury prevention and elite athletic mastery. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Jan 201351min

Podcast #34: The Perfect Health Diet with Paul Jaminet

Podcast #34: The Perfect Health Diet with Paul Jaminet

Paul Jaminet. Ph.D. was an astrophysicist at the Harvard-Smithsonian Center for Astrophysics, became a software entrepreneur during the Internet boom, and now provides strategic advice to entrepreneurial companies while pursuing research in economics. Paul’s experience overcoming a chronic illness has been key to his views of aging and disease, and in writing his new book Perfect Diet Solution. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Des 201240min

Podcast #33: Injury prevention and Wellness with Dr. Justin Marchegiani

Podcast #33: Injury prevention and Wellness with Dr. Justin Marchegiani

Dr. Justin Marchegiani is a graduate of the University of Massachusetts at Amherst with a B.S. degree in Kinesiology and Pre-medical studies. Dr. Justin has completed his Doctorate degree in Chiropractic Medicine from Life West University. Dr. Justin has completed post graduate study in the area of clinical nutrition, exercise and functional medicine so he can offer the most cutting edge techniques to help address his patient’s growing health care needs. Justin is head of Just In Health Wellness Clinic, a leading systems and functional medical provider who treats patients and athletes using biohacking and quantification. He can help you Bulletproof your game through education on injury prevention and performance enhancement! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Des 201236min

Podcast #32: Hacking your Heart and Preventing Diabetes with Dr. Rocky Patel

Podcast #32: Hacking your Heart and Preventing Diabetes with Dr. Rocky Patel

Dr. Patel is a Bulletproof Physician.  He is a family physician whose practice is focused on the prevention, early detection and treatment of Diabetes and Heart Attack.  He knows his stuff, he lost over 85 lbs practicing what he preaches. He uses Bulletproof diet principles in treating patients in his practice at risk for or who have developed diabetes and/or cardiovascular disease.   In addition, he is the chief medical officer for Heart Fit for Duty, providing similar services to the first responder community.  For those of you interested in WellnessFx in Arizona, he is a WellnessFX practitioner and his family medical practice is based in Gilbert, Arizona.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Nov 20121h 15min

Podcast #31: Hack Your Sleep with Dr. Jonathan Wisor, Ph.D.

Podcast #31: Hack Your Sleep with Dr. Jonathan Wisor, Ph.D.

Dr. Wisor is one of the foremost researchers on sleep and nervous system function.  His laboratory is funded by both the Department of Defense and the National Institute of Neurological Disorders and Stroke to apply molecular genetic and biochemical techniques to study sleep. Dr. Wisor comes on the show today to talk about how you can use biochemistry and the latest research to improve sleep and your quality of life. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Sep 20121h 16min

Podcast #30: Sweet Potato Power with Ashley Tudor

Podcast #30: Sweet Potato Power with Ashley Tudor

Ashley Tudor is a Design Strategist with the Spruce Street Institute where she works to create innovations in healthcare for doctors, patients and kids. She has worked with a wide range of Fortune 500 companies on a variety of projects including envisioning the future of cars, finding new ways for people to invest their money, designing ways to help food companies fight obesity, and coming up with new medical devices for primary care physicians. Ashley was named one of San Francisco’s Top Innovators in Health in 2010.Aside from her business exploits, Ashley is the author of Sweet Potato Power, a book aimed at promoting what she believes to be one of the healthiest and most high performance foods you can eat.  Ashley comes on Upgraded Self Radio to talk about how you can use the power of sweet potatoes to look, feel, and perform better. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Aug 20121h 12min

Podcast #29: How Real Food Improves Your Performance with Joel Salatin

Podcast #29: How Real Food Improves Your Performance with Joel Salatin

Joel F. Salatin is an American farmer, lecturer, and author whose books include Folks, This Ain't Normal, You Can Farm, and Salad Bar Beef. Salatin raises livestock using holistic methods of animal husbandry, free from harmful chemicals, on his Polyface Farm in Swoope, Virginia, in the Shenandoah Valley. Joel joins us today to talk about his unique farming methods, and why they improve both your health, and the health of the animals. Click here to subscribe to the podcast in iTunes. Click here to read the free transcript of this episode (coming soon). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jun 20121h 20min

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