TWiV #85 - Hepatitis C virus with Professor Michael Gale

TWiV #85 - Hepatitis C virus with Professor Michael Gale

On episode #85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses.

Host links Vincent Racaniello and Michael Gale

Links for this episode:
  • The Gale Laboratory at the University of Washington
  • Incredible view from the Gale laboratory (jpg)
  • Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses (review)
  • New potent HCV inhibitor
  • HCV virion and genome structures at ViralZone

Episoder(1346)

TWiV 457: The Red Queen meets the White Rabbit

TWiV 457: The Red Queen meets the White Rabbit

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit populatio...

3 Sep 20172h 3min

TWiV 456: Be careful of canons

TWiV 456: Be careful of canons

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor. Hosts: Vincent Racan...

26 Aug 20172h 4min

TWiV 455: Pork and genes

TWiV 455: Pork and genes

Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with se...

20 Aug 20171h 45min

TWiV 454: FGCU, Zika

TWiV 454: FGCU, Zika

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Rac...

13 Aug 20171h 47min

TWiV 453: Neurovirology with Diane Griffin

TWiV 453: Neurovirology with Diane Griffin

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system...

6 Aug 20171h 3min

TWiV 452: Kiss that frog

TWiV 452: Kiss that frog

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection...

29 Jul 20171h 52min

TWiV 451: Expectorate the unexpected

TWiV 451: Expectorate the unexpected

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello, Alan Dove, ...

23 Jul 20171h 44min

TWiV 450: Ben tenOever and RNA out

TWiV 450: Ben tenOever and RNA out

Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA rec...

16 Jul 20171h 35min

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